Katargina L A, Sidorova T V, Chesnokova N B, Kuznetsova T P
Vestn Oftalmol. 2003 Mar-Apr;119(2):20-1.
The method of chemiluminescence in the system of hemoglobin-peroxide hydrogen-luminal was made use of to study the antioxidant activity (AOA) of lacrimal fluid and blood serum in 20 children with endogenous uveitis. As uveitis aggravated, there is observed a reduced AOA both in lacrimal fluid and blood serum. As the inflammatory process is arrested, AOA begins to go down gradually; moreover, it approaches the values in the control group. The correlation between the lacrimal fluid AOA and the blood serum AOA was calculated and analyzed for each eye for the moment of examination. The low values of the coefficient were found for the constantly relapsing uveitis, while the high values were typical for the initial remission phase. A study of the correlation between the blood serum AOA and the lacrimal fluid AOA showed a low correlation coefficient (r = 0.3) during the uveitis aggravation period and its increase during the remission period (r = 0.7). The obtained data are indicative of that the free-radical processes are involved in the pathogenesis of endogenous uveitis; they also show that it is advisable to study the lacrimal-fluid and blood-serum AOAs in order to forecast the above disease and to choose an optimal therapy methods.
采用血红蛋白 - 过氧化氢 - 鲁米诺体系中的化学发光法，对20例内因性葡萄膜炎患儿的泪液和血清抗氧化活性（AOA）进行研究。随着葡萄膜炎病情加重，观察到泪液和血清中的AOA均降低。随着炎症过程得到控制，AOA开始逐渐下降；此外，它接近对照组的值。在检查时，对每只眼睛计算并分析泪液AOA与血清AOA之间的相关性。对于持续复发的葡萄膜炎，发现系数值较低，而在初始缓解期则典型地呈现高值。对血清AOA与泪液AOA之间相关性的研究表明，在葡萄膜炎加重期相关系数较低（r = 0.3），而在缓解期其升高（r = 0.7）。所获得的数据表明自由基过程参与内因性葡萄膜炎的发病机制；它们还表明，研究泪液和血清AOA对于预测上述疾病以及选择最佳治疗方法是可取的。
