Krichevskaia G I, Andzhelov V O, Katargina L A, Khvatova A V, Denisova E V, Zvonarev A Iu, Kuliakina M N, Zaĭtsev I Z
Vestn Oftalmol. 1999 Sep-Oct;115(5):23-5.
A total of 405 children aged 3 months to 15 years with uveitis of different origin and localization and 50 mothers of children with intrauterine uveitis were tested for cytomegaloviruses (CMV). Chronic CMV infection was detected in 79% children and 88% mothers. Active CMV infection was diagnosed in 7.1% children with various clinical forms of uveitis; it was somewhat more frequent in cases with grave posterior uveitis and panuveitis complicated by detachment of the retina and vitreous fibrosis. Anti-CMV IgG antibodies indicate an infection, but their detection is insufficient for identifying the etiology of uveitis. Active CMV infection can be a cause of uveitis or aggravate uveitis of another etiology and favor the development of postoperative complications. In many cases active CMV infection was detected in children during remission without clinical signs of uveitis activity. Individual analysis of clinical laboratory data is needed for each patient in order to evaluate the etiological and pathogenetic role of active CMV infection.
对405名年龄在3个月至15岁、患有不同病因和部位葡萄膜炎的儿童以及50名患有宫内葡萄膜炎儿童的母亲进行了巨细胞病毒（CMV）检测。在79%的儿童和88%的母亲中检测到慢性CMV感染。在7.1%患有各种临床类型葡萄膜炎的儿童中诊断出活动性CMV感染；在严重后葡萄膜炎和伴有视网膜脱离及玻璃体纤维化的全葡萄膜炎病例中，其发生率略高。抗CMV IgG抗体表明存在感染，但检测到它们不足以确定葡萄膜炎的病因。活动性CMV感染可能是葡萄膜炎的病因，或加重另一种病因的葡萄膜炎，并促使术后并发症的发生。在许多病例中，在儿童病情缓解期间检测到活动性CMV感染，且无葡萄膜炎活动的临床体征。为了评估活动性CMV感染的病因和发病机制作用，需要对每位患者进行临床实验室数据的个体分析。
