Couce M E, Perry A, Webb P, Kepes J J, Scheithauer B W
Department of Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Ultrastruct Pathol. 1999 Sep-Oct;23(5):341-5. doi: 10.1080/019131299281491.
A 58-year-old African-American woman presented with a 6-month history of headaches. A magnetic resonance imaging scan of the head revealed a 5-cm, enhancing dura-based mass in the left parietal region. The variably cellular tumor was composed of uniform spindle cells associated with intercellular collagen and numerous radially arranged "petal-shaped" clusters of eosinophilic crystals. The tumor was diagnosed by light microscopy as a fibrous meningioma. Ultrastructural examination disclosed cells with complex interdigitating processes connected by desmosome-like cell junctions, abundant intercellular collagen fibers, and prominent, densely osmiophilic crystals featuring radiating teardrop shaped petals emanating from a central core. A positive Millon reaction showed these crystals to consist at least in part of tyrosine. By morphology, histochemistry, and ultrastructure, the crystals resembled tyrosine-rich crystals occurring in salivary gland tumors. This is the first report of a fibrous meningioma containing tyrosine-rich crystals.
一名58岁的非裔美国女性因头痛6个月前来就诊。头部磁共振成像扫描显示左顶叶区域有一个5厘米大小、强化的硬脑膜肿块。该肿瘤细胞成分多样，由均匀的梭形细胞组成，伴有细胞间胶原纤维以及众多呈放射状排列的“花瓣状”嗜酸性晶体簇。通过光学显微镜检查，该肿瘤被诊断为纤维性脑膜瘤。超微结构检查发现细胞具有复杂的相互交错的突起，通过类似桥粒的细胞连接相连，细胞间有丰富的胶原纤维，还有突出的、嗜锇性强的晶体，这些晶体呈放射状泪滴形花瓣，从中心核发出。米隆反应呈阳性，表明这些晶体至少部分由酪氨酸组成。从形态、组织化学和超微结构来看，这些晶体类似于唾液腺肿瘤中出现的富含酪氨酸的晶体。这是关于含有富含酪氨酸晶体的纤维性脑膜瘤的首次报告。
