亚速尔群岛HUMTH01、HUMVWA31/A、HUMF13A1和HUMFES/FPS系统的群体研究

Population study of HUMTH01, HUMVWA31/A, HUMF13A1, and HUMFES/FPS systems in Azores.

作者信息

Corte-Real F, Souto L, Anjos M J, Carvalho M, Vieira D N, Carracedo A, Vide M C

机构信息

Institute of Legal Medicine, Faculty of Medicine, University of Coimbra, Portugal.

出版信息

J Forensic Sci. 1999 Nov;44(6):1261-4.

PMID:10582365

Abstract

The tetrameric short tandem repeat polymorphisms HUMTH01, HUMVWA31/A, HUMF13A1, and HUMFES/FPS were studied in blood stains obtained from a population of unrelated individuals from the Azores Archipelago (Portugal). Gene frequencies were determined and no deviation from the Hardy-Weinberg equilibrium was found. However, the allelic independence test between loci showed linkage disequilibrium between HUMVWA31/A and HUMFES/FPS. A combined discrimination power and chance of exclusion of, respectively, 0.9999 and 0.9534, reveal the high forensic interest of the four systems. No differences with other caucasoid populations were found, but comparison with some asiatic, eskimo, and amerindian populations showed significant statistical differences.

摘要

对来自亚速尔群岛（葡萄牙）一群无关个体的血迹样本，研究了四聚体短串联重复序列多态性HUMTH01、HUMVWA31/A、HUMF13A1和HUMFES/FPS。确定了基因频率，未发现偏离哈迪-温伯格平衡的情况。然而，位点间的等位基因独立性检验显示HUMVWA31/A和HUMFES/FPS之间存在连锁不平衡。联合鉴别力和排除机会分别为0.9999和0.9534，表明这四个系统具有很高的法医鉴定价值。未发现与其他高加索人群有差异，但与一些亚洲、爱斯基摩和美洲印第安人群的比较显示出显著的统计学差异。