马德拉群岛（葡萄牙）六个聚合酶链反应扩增位点的群体分布
Population distribution of six PCR-amplified loci in Madeira Archipelago (Portugal).
作者信息
Corte-Real F, Souto L, Anjos M J, Carvalho M, Vieira D N, Carracedo A, Vide M C
机构信息
Institute of Legal Medicine, Faculty of Medicine, University of Coimbra, Portugal.
出版信息
Forensic Sci Int. 1999 Mar 15;100(1-2):93-9. doi: 10.1016/s0379-0738(98)00202-3.
Frequency data of the short tandem repeat (STR) loci HUMTH01, HUMVWA31/A, HUMF13A1, HUMFES/FPS, D12S391 and HUMFIBRA/FGA were determined in blood stains obtained from a population of unrelated individuals from the Madeira Archipelago. The observed genotype distribution showed no significant deviation from the Hardy-Weinberg equilibrium and there was no evidence for association of alleles among the six loci. Population data showed a combined discrimination power of 0.9999998 and a chance of exclusion of 0.99597. The frequencies are similar to those of other compared caucasian populations but significant differences were found between the Madeira population and Japanese, Chinese, Greenland Eskimos and Quechua Amerindians. The six loci studied, together proved to be highly discriminating and valuable for forensic cases.
在从马德拉群岛无关个体群体获取的血迹中，测定了短串联重复序列（STR）基因座HUMTH01、HUMVWA31/A、HUMF13A1、HUMFES/FPS、D12S391和HUMFIBRA/FGA的频率数据。观察到的基因型分布与哈迪-温伯格平衡无显著偏差，且没有证据表明这六个基因座之间的等位基因存在关联。群体数据显示联合鉴别力为0.9999998，排除概率为0.99597。这些频率与其他比较的高加索人群体相似，但马德拉人群体与日本人、中国人、格陵兰爱斯基摩人和克丘亚美洲印第安人之间存在显著差异。所研究的六个基因座共同证明对法医案件具有高度鉴别力且很有价值。
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