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一项针对法医目的对STR基因座HUMTHO1、HUMFES/FPS、HUMVWA31/1和HUMF13A1进行的荷兰人群研究。

A Dutch population study of the STR Loci HUMTHO1, HUMFES/FPS, HUMVWA31/1 and HUMF13A1, conducted for forensic purposes.

作者信息

Sjerps M, van der Geest N, Pieron C, Gajadhar M, Kloosterman A

机构信息

Netherlands Forensic Science Institute, Netherlands.

出版信息

Int J Legal Med. 1995;108(3):127-34. doi: 10.1007/BF01844823.

Abstract

We report on a Dutch population study of the STR loci HUMTHO1, HUMFES/FPS, HUMVWA31/1, and HUMF13A1, in which we used multiplex amplification and automated fragment detection. Genotype and allele frequencies showed no deviation from Hardy-Weinberg and linkage equilibrium. The improved Bonferroni procedure was used to combine the results of several tests. The power of discrimination of a complete profile exceeded 0.9998. We compared the allele frequencies in the Dutch sample to the frequencies in other populations using a bipilot to visualize alleles and populations simultaneously. The Dutch sample was similar to most other Caucasian samples. The data demonstrate that the genetic systems in this report are a valuable tool for forensic identity testing in The Netherlands.

摘要

我们报告了一项针对STR基因座HUMTHO1、HUMFES/FPS、HUMVWA31/1和HUMF13A1的荷兰人群研究,其中我们采用了多重扩增和自动片段检测。基因型和等位基因频率未偏离哈迪-温伯格平衡和连锁平衡。采用改进的邦费罗尼程序来合并多项测试的结果。完整图谱的鉴别力超过0.9998。我们使用双试点法将荷兰样本中的等位基因频率与其他人群中的频率进行比较,以便同时直观显示等位基因和人群。荷兰样本与大多数其他白种人样本相似。数据表明,本报告中的遗传系统是荷兰法医身份鉴定的宝贵工具。

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