泰国非霍奇金淋巴瘤患者的人类白细胞抗原II类多态性

HLA class II polymorphism in Thai patients with non-Hodgkin's lymphoma.

作者信息

Nathalang O, Tatsumi N, Hino M, Prayoonwiwat W, Yamane T, Suwanasophon C, Sriphaisal T

机构信息

Department of Pathology, Pramongkutklao College of Medicine, Bangkok, Thailand.

出版信息

Eur J Immunogenet. 1999 Dec;26(6):389-92. doi: 10.1046/j.1365-2370.1999.00177.x.

DOI:10.1046/j.1365-2370.1999.00177.x

PMID:10583459

Abstract

The distribution of HLA-DRB1 alleles and DQB1 alleles in 100 Thai patients with non-Hodgkin's lymphoma (NHL) was analysed using the polymerase chain reaction with sequence-specific primer (PCR-SSP) method, and the association between the disease and the presence of certain HLA class II alleles was investigated. The frequencies of HLA-DRB11502 and DRB109012 were increased while those of DRB10404, DRB10803 and DRB11106 were decreased. On the other hand, the incidence of HLA-DQB1 alleles was similar to that in the normal population. Interestingly, only HLA-DRB11502 showed a significant positive association with NHL, especially in patients < or / = 45 years and in male patients. It is concluded that the DRB1*1502 allele may contribute to NHL susceptibility in the Thai population. However, further studies on the functional roles of the HLA class II alleles are necessary to elucidate NHL susceptibility.

摘要

采用聚合酶链反应和序列特异性引物（PCR-SSP）方法分析了100例泰国非霍奇金淋巴瘤（NHL）患者的HLA-DRB1等位基因和DQB1等位基因分布，并研究了该疾病与某些HLA II类等位基因存在之间的关联。HLA-DRB11502和DRB109012的频率增加，而DRB10404、DRB10803和DRB11106的频率降低。另一方面，HLA-DQB1等位基因的发生率与正常人群相似。有趣的是，只有HLA-DRB11502与NHL呈显著正相关，尤其是在年龄≤45岁的患者和男性患者中。得出的结论是，DRB1*1502等位基因可能与泰国人群的NHL易感性有关。然而，有必要对HLA II类等位基因的功能作用进行进一步研究，以阐明NHL易感性。