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基因距离的基因座间变异与中性突变理论。

Interlocus variation of genetic distance and the neutral mutation theory.

作者信息

Nei M, Tateno Y

出版信息

Proc Natl Acad Sci U S A. 1975 Jul;72(7):2758-60. doi: 10.1073/pnas.72.7.2758.

DOI:10.1073/pnas.72.7.2758
PMID:1058490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC432850/
Abstract

Theoretical distributions of genetic distance between reproductively isolated taxa are derived by means of computer simulation, taking into account mutation and random genetic drift. The distributions obtained are in good agreement with the observed distributions of interracial and interspecific genetic distances for enzymes loci in Drosophila. This indicates that the gene substitution at enzyme loci can be explained by the neutral mutation theory.

摘要

通过计算机模拟，考虑到突变和随机遗传漂变，得出了生殖隔离类群之间遗传距离的理论分布。所得分布与果蝇中酶基因座的种间和种内遗传距离的观察分布高度一致。这表明酶基因座上的基因替代可以用中性突变理论来解释。

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本文引用的文献

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THE MAINTENANCE OF ALLELES BY MUTATION.通过突变维持等位基因
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THE NUMBER OF ALLELES THAT CAN BE MAINTAINED IN A FINITE POPULATION.有限种群中能够维持的等位基因数量。
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Protein polymorphism as a phase of molecular evolution.蛋白质多态性作为分子进化的一个阶段。
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Genetic variation in natural populations of five Drosophila species and the hypothesis of the selective neutrality of protein polymorphisms.五种果蝇自然种群中的遗传变异与蛋白质多态性的选择中性假说。
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Genic variation within and between the three major races of man, Caucasoids, Negroids, and Mongoloids.人类三大主要种族，即高加索人种、尼格罗人种和蒙古人种内部以及之间的基因变异。
Am J Hum Genet. 1974 Jul;26(4):421-43.
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Gene frequency comparisons between taxa: support for the natural selection of protein polymorphisms.不同分类群之间的基因频率比较：对蛋白质多态性自然选择的支持。
Proc Natl Acad Sci U S A. 1974 Dec;71(12):4847-9. doi: 10.1073/pnas.71.12.4847.