杂合性与遗传距离的抽样方差。
Sampling variances of heterozygosity and genetic distance.
作者信息
Nei M, Roychoudhury A K
出版信息
Genetics. 1974 Feb;76(2):379-90. doi: 10.1093/genetics/76.2.379.
Abstract
Mathematical formulae for the sampling variances of average heterozygosity and Nei's genetic distance are developed. These sampling variances are decomposed into their two components, i.e. the inter-locus and intra-locus variances. The relationship between the number of loci and the number of individuals per locus to be examined for estimating average heterozygosity and genetic distance is also discussed. The utility of the inter-locus variance of heterozygosity for studying the mechanism of maintenance of genetic variability in populations is indicated.
摘要
推导了平均杂合度和内氏遗传距离抽样方差的数学公式。这些抽样方差被分解为两个组成部分，即位点间方差和位点内方差。还讨论了用于估计平均杂合度和遗传距离时所检测的位点数与每个位点个体数之间的关系。指出了杂合座位间方差在研究群体遗传变异性维持机制方面的用途。
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