Adorno G, Zinno F, Bruno A, Lanti A, Ballatore G, Masi M, Cudillo L, Del Poeta G, Riccitelli A, Del Principe M I, Pepe R, Marchitelli E, Morosetti M, Meloni C, Isacchi G, Amadori S
Department of Hematology, University of Roma Tor Vergata St. Eugenio Hospital, Italy.
Int J Artif Organs. 1999 Oct;22(10):710-2.
Central venous access is necessary in patients candidate for peripheral blood stem cell (PBSC) collection. We report our experience with a dual lumen femoral catheter (Gamcath, 11 french), initially designed for hemodialysis. We studied 147 patients and performed 488 collections after mobilization with either G-CSF alone or chemotherapy + G-CSF, when the white blood cell count exceeded 1 x 10(9)/L, or when a measurable population of CD34+ cells (20/microL) was detected in peripheral blood. All patients received systemic anticoagulation with a low weight heparin and ultrasound examination was performed after the removal of the catheter. Seven patients developed thrombosis (4.7%), ten experienced hematomas at the site of catheter placement (6.8%) despite prophylactic platelet transfusions, while only one patient (0.6%) had a catheter-related infection. In conclusion, the short-term use of large bore femoral catheters in setting up PBSC collection seems to be associated with minimal risk of infection and low thrombotic incidence.
对于适合进行外周血干细胞（PBSC）采集的患者，中心静脉通路是必要的。我们报告了我们使用最初为血液透析设计的双腔股静脉导管（Gamcath，11法式）的经验。我们研究了147例患者，在单独使用粒细胞集落刺激因子（G-CSF）或化疗+G-CSF动员后，当白细胞计数超过1×10⁹/L，或在外周血中检测到可测量的CD34⁺细胞群（20/μL）时，进行了488次采集。所有患者均接受低剂量肝素全身抗凝，并在拔除导管后进行超声检查。7例患者发生血栓形成（4.7%），10例患者尽管预防性输注血小板，但在导管置入部位出现血肿（6.8%），而只有1例患者（0.6%）发生导管相关感染。总之，在建立PBSC采集时短期使用大口径股静脉导管似乎与感染风险最小和血栓形成发生率低相关。
