Shariatmadar S, Noto T A
Department of Pathology, Transfusion Medicine Services, University of Miami/Jackson Memorial Medical Center, Florida, USA.
J Clin Apher. 1998;13(3):99-102. doi: 10.1002/(sici)1098-1101(1998)13:3<99::aid-jca1>3.0.co;2-#.
Central venous catheters are used frequently in large-volume leukapheresis to provide high flow rates for peripheral blood progenitor cell (PBPC) collection. In a retrospective study, we evaluated the safety and efficacy of short-term use of large-bore femoral venous catheters for the collection of PBPCs in 63 patients with hematologic and solid organ malignancies. All catheters were placed in an outpatient setting on the day of apheresis and remained in site if subsequent collections became necessary. A total of 101 procedures were performed. Thirty-five patients (56%) reached target levels after 1 collection. Twenty-four patients (38%) had 2 consecutive day collections while 4 patients (6%) required more than 2 collections. In this latter group, 2 patients did not have consecutive day collections. One had 2 consecutive day collections followed by a third collection 48 hours later. In the other, leukapheresis was performed for 2 consecutive days and then resumed 3 days later with 2 subsequent collections. The longest duration the catheter remained in site was 6 days. Catheter care was provided by the apheresis staff. All patients who had more than 1 collection were given instructions on how to care for their catheters at home. Only 1 patient had oozing at the catheter site during the collection. Thrombosis, mechanical, and infectious complications were not encountered. The short-term use of femoral venous catheters appears safe and effective for the collection of PBPCs.
中心静脉导管在大容量白细胞单采术中经常使用，以提供高流速用于外周血祖细胞（PBPC）采集。在一项回顾性研究中，我们评估了63例血液系统和实体器官恶性肿瘤患者短期使用大口径股静脉导管采集PBPC的安全性和有效性。所有导管均在单采术当天在门诊放置，如果后续需要采集则保留在位。共进行了101次操作。35例患者（56%）在1次采集后达到目标水平。24例患者（38%）连续2天进行采集，4例患者（6%）需要超过2次采集。在后一组中，2例患者没有连续采集。1例患者连续2天采集，48小时后进行第三次采集。另一例患者连续2天进行白细胞单采术，然后在3天后恢复，随后又进行了2次采集。导管在位的最长时间为6天。导管护理由单采术工作人员提供。所有进行了不止1次采集的患者都接受了在家中如何护理导管的指导。只有1例患者在采集过程中导管部位有渗血。未遇到血栓形成、机械性和感染性并发症。股静脉导管的短期使用对于PBPC采集似乎是安全有效的。
