Van Spaendonck M P, Timmermans J P, Claes J, Scheuermann D W, Wuyts F L, Van de Heyning P H
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital, Antwerp, Edegem, Belgium.
Acta Otolaryngol. 1999;119(6):685-9. doi: 10.1080/00016489950180630.
Mesna (Mistabron) is a mucolytic substance that is also used for chemically assisted dissection during cholesteatoma surgery. The present animal study aims to evaluate its possible ototoxic side effects. To this end, the right tympanic cavity of 9 guinea pigs was filled with either 20% mesna or 10% neomycin (serving as a positive control), while the left tympanic cavity was filled with saline (serving as a negative control). One week after administration, the inner ears were dissected out and further processed for morphological evaluation by means of either interference contrast microscopy or scanning electron microscopy. No macroscopic signs of middle ear inflammation were observed in any of the ears treated. Whereas damage was obvious in all neomycin-treated specimens, the morphology of both saline- and mesna-treated inner ears was unaffected. These findings led us to conclude that, at least on a morphological basis, no indications are at hand to assume ototoxic effects of this mucolytic substance due to a single application during cholesteatoma surgery.
美司钠（Mistabron）是一种黏液溶解剂，也用于胆脂瘤手术中的化学辅助剥离。本动物研究旨在评估其可能的耳毒性副作用。为此，向9只豚鼠的右鼓室内注入20%的美司钠或10%的新霉素（作为阳性对照），而左鼓室内注入生理盐水（作为阴性对照）。给药一周后，取出内耳并通过干涉对比显微镜或扫描电子显微镜进一步处理以进行形态学评估。在所有接受治疗的耳朵中均未观察到中耳炎症的宏观迹象。虽然在所有新霉素治疗的标本中损伤明显，但生理盐水和美司钠治疗的内耳形态均未受影响。这些发现使我们得出结论，至少在形态学基础上，没有迹象表明在胆脂瘤手术中单次应用这种黏液溶解剂会产生耳毒性作用。
