美司钠和 5-氟尿嘧啶对丙二醇诱导大鼠胆脂瘤的抑制作用。
Inhibitory effect of mesna and 5-fluorouracil on propylene glycol-induced cholesteatoma in rats.
机构信息
Istanbul Medeniyet University, Faculty of Medicine, Goztepe Training and Research Hospital, Department of Otorhinolaryngology, Istanbul, Turkey.
Istanbul Medeniyet University, Faculty of Medicine, Goztepe Training and Research Hospital Department of Pathology, Istanbul, Turkey.
出版信息
Acta Otorhinolaryngol Ital. 2021 Oct;41(5):481-486. doi: 10.14639/0392-100X-N1392.
OBJECTIVE
The aim of this study was to investigate the inhibitory effect of different doses of sodium-2-mercaptoethanesulphonate (MESNA) and 5-fluorouracil on cholesteatoma formation.
METHODS
Fifty-six Wistar albino male rats were divided into seven groups with eight rats in each. On the first, eighth and fifteenth days, 0.2 ml of saline was administered to the group 1 (control group), and propylene glycol to induce cholesteatoma the other groups. On the 22 day of the study, 0.2 ml saline was given to Group 1 and Group 2. Groups 3 to 7 were treated with 0.2 ml 100% MESNA, 0.2 ml 50% MESNA, 0.2 ml 20% MESNA, 0.2 ml 5-fluorouracil and 0.1 ml 100% MESNA plus 0.1 ml 5-fluorouracil, respectively, with all applications performed by intratympanic injection.
RESULTS
Significant differences were found between Group 1 and all other groups except Group 3. Significant differences were also found between Group 3 and Groups 2, 5 and 6 (P < 0.05).
CONCLUSIONS
According to the results of this study, experimental cholesteatoma induced with propylene glycol may be inhibited by MESNA at 100% concentration.
目的
本研究旨在探讨不同剂量的巯乙磺酸钠（MESNA）和 5-氟尿嘧啶对胆脂瘤形成的抑制作用。
方法
56 只 Wistar 白化雄性大鼠分为 7 组，每组 8 只。第 1、8 和 15 天，第 1 组（对照组）给予 0.2ml 生理盐水，其余各组给予丙二醇诱导胆脂瘤。研究第 22 天，第 1 组和第 2 组给予 0.2ml 生理盐水。第 3 至 7 组分别给予 0.2ml100%MESNA、0.2ml50%MESNA、0.2ml20%MESNA、0.2ml5-氟尿嘧啶和 0.1ml100%MESNA 加 0.1ml5-氟尿嘧啶，均通过鼓室内注射给药。
结果
第 1 组与除第 3 组以外的所有组之间存在显著差异。第 3 组与第 2、5 和 6 组之间也存在显著差异（P<0.05）。
结论
根据本研究结果，100%浓度的 MESNA 可能抑制丙二醇诱导的实验性胆脂瘤。
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