Durak H, Aktoğu S, Değirmenci B, Sayit E, Ertay T, Dereli S
Department of Nuclear Medicine, Dokuz Eylül University School of Medicine, Izmir, Turkey.
Nucl Med Biol. 1999 Aug;26(6):695-8. doi: 10.1016/s0969-8051(99)00037-2.
We have investigated Technetium 99m erythromycin lactobionate (Tc 99m EL) clearance from the lungs after inhalation, in the presence of an alveolitis. Eighteen patients (6 sarcoidosis, 7 idiopathic fibrosis, and 5 miliary tuberculosis) were imaged after the patients inhaled 1,110 MBq of Tc 99m EL. Clearance half time for the first 45 min, for 24 h, and retention at 24 h correlated with percentage of lymphocytes in bronchoalveolar lavage fluid (BAL) (r = .729, r = .883, and r = .826, respectively). There was a positive correlation between peripheral penetration (PP) and forced expiratory volume in 1 s (FEV1) (r = .806) and forced vital capacity (FVC) (r = .781). Retention was more marked in sarcoidosis compared with tuberculosis (0.025 < p < or = 0.05). Radioaerosol lung imaging may reflect the pulmonary function impairment in parenchymal lung diseases. Retention of Tc 99m EL may be related to number of BAL cells or presence of a lymphocytic alveolitis. Long residency time of Tc 99m EL in the lungs implies that erythromycin can also be administered by inhalation for therapeutic purposes.
我们研究了在存在肺泡炎的情况下，吸入后肺对99m锝红霉素乳糖酸盐（Tc 99m EL）的清除情况。18例患者（6例结节病、7例特发性肺纤维化和5例粟粒性肺结核）吸入1110MBq的Tc 99m EL后进行成像。前45分钟、24小时的清除半衰期以及24小时的滞留情况与支气管肺泡灌洗（BAL）液中淋巴细胞百分比相关（分别为r = 0.729、r = 0.883和r = 0.826）。外周肺穿透率（PP）与1秒用力呼气量（FEV1）（r = 0.806）和用力肺活量（FVC）（r = 0.781）之间存在正相关。与肺结核相比，结节病中的滞留更为明显（0.025 < p ≤ 0.05）。放射性气溶胶肺成像可能反映实质性肺部疾病中的肺功能损害。Tc 99m EL的滞留可能与BAL细胞数量或淋巴细胞性肺泡炎的存在有关。Tc 99m EL在肺中的长时间停留意味着红霉素也可通过吸入给药用于治疗目的。
