Durak H, Ertay T, Sayit E, Aktoğu S, Kut O, Güven H, Güre A
Dokuz Eylül University School of Medicine, Department of Nuclear Medicine, Izmir, Turkey.
Nucl Med Biol. 1996 Apr;23(3):291-3. doi: 10.1016/0969-8051(95)02080-2.
In order to assess the lung clearance of aerosolized 99mTc Erythromycin Lactobionate (EL), 99mTc EL was administered to 9 New Zealand rabbits by inhalation. 5 rabbits inhaled cigarette smoke before 99mTc EL. Clearance half times were 3.0 +/- 0.9 hours in normals, 5.5 +/- 1.0 hours after smoke exposure. Clearance was not affected after destroying the surfactant layer. Slower clearance after smoke exposure may be due to the inhibition of mucociliary clearance. 99mTc EL can be considered as an alternative radioaerosol for ventilation imaging.
为了评估雾化的99m锝乳糖酸红霉素（EL）的肺清除情况，通过吸入方式给9只新西兰兔注射了99m锝EL。5只兔子在注射99m锝EL之前吸入了香烟烟雾。正常情况下清除半衰期为3.0±0.9小时，烟雾暴露后为5.5±1.0小时。破坏表面活性物质层后清除情况未受影响。烟雾暴露后清除较慢可能是由于黏液纤毛清除功能受到抑制。99m锝EL可被视为通气成像的一种替代放射性气溶胶。
