巴豆叶巴豆中克罗烷二萜反式脱氢巴豆素的遗传毒性活性研究。
Investigation of genotoxic activity of trans-dehydrocrotonin, a clerodane diterpene from Croton cajucara.
作者信息
Agner A R, Maciel M A, Pinto A C, Pamplona S G, Cólus I M
机构信息
Departamento de Biologia Geral, CCB-UEL-Pr-Brazil, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Campus Universitário, Londrina (Pr), Brazil.
出版信息
Teratog Carcinog Mutagen. 1999;19(6):377-84. doi: 10.1002/(sici)1520-6866(1999)19:6<377::aid-tcm2>3.0.co;2-t.
The genotoxic action of three doses of trans-dehydrocrotonin (t-DCTN), an active ingredient obtained from the bark extracts of an Amazon native plant, Croton cajucara, were examined in Swiss mouse bone marrow cells in vivo, submitted to acute intraperitoneal treatment, by micronucleus (MN) and chromosomal aberration (CA) tests. The statistical tests (Anova and Tukey) made to compare the results obtained in each of the three doses of t-DCTN with the negative-control group showed that the frequencies of MN and mitotic index were equal to the negative-control and that the frequencies of CA were lower than that observed in the negative-control. Therefore, based on our results it can be said that t-DCTN is not genotoxic nor cytotoxic to mouse bone marrow cells, submitted to acute intraperitoneal treatment in vivo. Teratogenesis Carcinog. Mutagen. 19:377-384, 1999.
从亚马逊本土植物巴豆（Croton cajucara）树皮提取物中获得的活性成分反式脱氢巴豆毒素（t-DCTN）的三种剂量的遗传毒性作用，通过微核（MN）和染色体畸变（CA）试验，在瑞士小鼠骨髓细胞体内进行了研究，这些小鼠接受了急性腹腔注射治疗。用于比较三种剂量的t-DCTN与阴性对照组结果的统计检验（方差分析和Tukey检验）表明，微核频率和有丝分裂指数与阴性对照组相等，染色体畸变频率低于阴性对照组。因此，根据我们的结果，可以说t-DCTN对接受急性腹腔注射治疗的小鼠骨髓细胞没有遗传毒性也没有细胞毒性。《致畸、致癌、致突变》19:377 - 384，1999年。
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