Rishani R, El-Khatib M, Mroueh S
Department of Pediatrics, American University of Beirut Medical Center, Beirut, Lebanon.
Pediatr Pulmonol. 1999 Dec;28(6):451-3. doi: 10.1002/(sici)1099-0496(199912)28:6<451::aid-ppul12>3.0.co;2-0.
The paper reports on a 13-year-old girl with chronic asthma who presented in acute respiratory failure following an exacerbation of her disease. Nitric oxide was added to the ventilator circuit at 7 ppm and then 15 ppm after the patient failed to respond to bronchodilators and steroids. This was followed by rapid improvement in respiratory mechanics and blood gases with no adverse effects. Nitric oxide appears to have a direct relaxing effect on the bronchial smooth muscle.
该论文报道了一名13岁的慢性哮喘女孩，在疾病加重后出现急性呼吸衰竭。在患者对支气管扩张剂和类固醇无反应后，一氧化氮以7 ppm的浓度添加到呼吸机回路中，随后增至15 ppm。此后呼吸力学和血气迅速改善，且无不良反应。一氧化氮似乎对支气管平滑肌有直接的舒张作用。
