Lymphocyte stimulation by autologous tumor cells in the presence of serum from the same patient or from healthy donors.

Lymphocyte blastogenesis induced by autologous tumor biopsy cells, by allogeneic lymphocytes and by PHA, was performed in the presence of autologous or allogeneic serum collected from normal blood donors. In 13 of the 15 cases lymphocyte stimulation by autologous tumor cells was inhibited in the presence of autologous serum. In contrast, autologous serum somewhat enhanced the blastogenic effect of PHA and allogeneic lymphocytes.