Vánky F, Willems J, Kreicbergs A, Aparisi T, Andréen M, Broström L A, Nilsonne U, Klein E, Klein G
Cancer Immunol Immunother. 1983;16(1):11-6. doi: 10.1007/BF00199899.
T-cell-enriched blood lymphocyte populations from 24 osteosarcoma and 22 soft-tissue sarcoma patients were assayed at the time of surgery for proliferative response to, and/or cytotoxic potential against autologous tumor cells. Tumor-free period and survival of the patients were correlated with the results obtained in the in vitro tests. The observation time was between 18 and 118 months (mean 62) for the osteosarcoma patients and between 18 and 72 (mean 42) for the patients with soft-tissue sarcoma. In both groups tumor-free period and survival were longer for those individuals who had auto-tumor reactivity. In the non-reactive group, all patients died within 3 years. Almost all patients had cytotoxicity against K562.
在手术时，对来自24例骨肉瘤患者和22例软组织肉瘤患者的富含T细胞的血液淋巴细胞群体进行了检测，以评估其对自体肿瘤细胞的增殖反应和/或细胞毒性潜力。患者的无瘤期和生存期与体外试验结果相关。骨肉瘤患者的观察时间为18至118个月（平均62个月），软组织肉瘤患者的观察时间为18至72个月（平均42个月）。在两组中，具有自体肿瘤反应性的个体的无瘤期和生存期更长。在无反应组中，所有患者均在3年内死亡。几乎所有患者对K562都具有细胞毒性。
