淋巴细胞介导的自身肿瘤反应性与临床病程的相关性。I. 46例肉瘤患者的评估
Correlation between lymphocyte-mediated auto-tumor reactivities and clinical course. I. Evaluation of 46 patients with sarcoma.
作者信息
Vánky F, Willems J, Kreicbergs A, Aparisi T, Andréen M, Broström L A, Nilsonne U, Klein E, Klein G
出版信息
Cancer Immunol Immunother. 1983;16(1):11-6. doi: 10.1007/BF00199899.
Abstract
T-cell-enriched blood lymphocyte populations from 24 osteosarcoma and 22 soft-tissue sarcoma patients were assayed at the time of surgery for proliferative response to, and/or cytotoxic potential against autologous tumor cells. Tumor-free period and survival of the patients were correlated with the results obtained in the in vitro tests. The observation time was between 18 and 118 months (mean 62) for the osteosarcoma patients and between 18 and 72 (mean 42) for the patients with soft-tissue sarcoma. In both groups tumor-free period and survival were longer for those individuals who had auto-tumor reactivity. In the non-reactive group, all patients died within 3 years. Almost all patients had cytotoxicity against K562.
摘要
在手术时，对来自24例骨肉瘤患者和22例软组织肉瘤患者的富含T细胞的血液淋巴细胞群体进行了检测，以评估其对自体肿瘤细胞的增殖反应和/或细胞毒性潜力。患者的无瘤期和生存期与体外试验结果相关。骨肉瘤患者的观察时间为18至118个月（平均62个月），软组织肉瘤患者的观察时间为18至72个月（平均42个月）。在两组中，具有自体肿瘤反应性的个体的无瘤期和生存期更长。在无反应组中，所有患者均在3年内死亡。几乎所有患者对K562都具有细胞毒性。
相似文献
1
Correlation between lymphocyte-mediated auto-tumor reactivities and clinical course. I. Evaluation of 46 patients with sarcoma.淋巴细胞介导的自身肿瘤反应性与临床病程的相关性。I. 46例肉瘤患者的评估
Cancer Immunol Immunother. 1983;16(1):11-6. doi: 10.1007/BF00199899.
2
Correlation between lymphocyte-mediated auto-tumor reactivities and the clinical course. II. Evaluation of 69 patients with lung carcinoma.淋巴细胞介导的自身肿瘤反应性与临床病程的相关性。II. 69例肺癌患者的评估
Cancer Immunol Immunother. 1983;16(1):17-22. doi: 10.1007/BF00199900.
3
Lysis of autologous tumor cells by blood lymphocytes tested at the time of surgery. Correlation with the postsurgical clinical course.手术时检测血液淋巴细胞对自体肿瘤细胞的溶解作用。与术后临床病程的相关性。
Cancer Immunol Immunother. 1986;21(1):69-76. doi: 10.1007/BF00199380.
4
The immune-status in patients with bone and soft-tissue sarcomas.骨肉瘤和软组织肉瘤患者的免疫状态。
Recent Results Cancer Res. 1976(54):197-205. doi: 10.1007/978-3-642-80997-2_16.
5
6
In vitro studies of cell mediated immunity to human sarcomas.针对人类肉瘤的细胞介导免疫的体外研究。
Osterr Z Onkol. 1974(3-4):89-96.
7
Tumor-specific immunity in sarcoma patients.肉瘤患者的肿瘤特异性免疫
Oncology. 1977;34(5):219-23. doi: 10.1159/000225228.
8
Specific antigen stimulated lymphocyte proliferation in osteosarcoma.特定抗原刺激骨肉瘤中的淋巴细胞增殖。
Cancer. 1976 Feb;37(2):743-50. doi: 10.1002/1097-0142(197602)37:2<743::aid-cncr2820370222>3.0.co;2-0.
9
Impaired lymphocyte responsiveness in osteosarcoma.骨肉瘤中淋巴细胞反应性受损。
J Surg Res. 1975 May;18(5):551-4. doi: 10.1016/0022-4804(75)90132-8.
10
Cellular immunity to human sarcoma.对人类肉瘤的细胞免疫。
J Natl Cancer Inst. 1971 Jun;46(6):1145-51.
引用本文的文献
1
Biological significance of autologous tumor-killing activity and its induction therapy.自体肿瘤杀伤活性的生物学意义及其诱导治疗
Cancer Immunol Immunother. 1993 Jul;37(2):75-83. doi: 10.1007/BF01517038.
2
Immunogenicity and immunosensitivity of ex vivo human carcinomas: interferon gamma and tumour necrosis factor alpha treatment of tumour cells potentiates their interaction with autologous blood lymphocytes.离体人癌的免疫原性和免疫敏感性：γ干扰素和肿瘤坏死因子α对肿瘤细胞的处理增强了它们与自体血淋巴细胞的相互作用。
Cancer Immunol Immunother. 1995 Oct;41(4):217-26. doi: 10.1007/BF01516996.
3
DR antigens expressed on tumor cells do not contribute to the blastogenetic response of autologous T cells.肿瘤细胞上表达的DR抗原对自体T细胞的母细胞生成反应没有作用。
Cancer Immunol Immunother. 1985;19(3):219-25. doi: 10.1007/BF00199230.
4
Activation of lymphocyte anti-tumour responses in man: effector heterogeneity and the search for immunomodulators.人类淋巴细胞抗肿瘤反应的激活：效应细胞异质性与免疫调节剂的探索。
Cancer Metastasis Rev. 1987;5(4):299-312. doi: 10.1007/BF00055375.
5
In vitro generation of tumour-specific lymphocyte reactivity to colonic carcinoma cells. Comparison with normal colonic mucosa cells.体外产生对结肠癌细胞的肿瘤特异性淋巴细胞反应。与正常结肠黏膜细胞的比较。
Cancer Immunol Immunother. 1987;25(3):209-14. doi: 10.1007/BF00199149.
6
Induction of human glioma-specific cytotoxic T-lymphocyte lines by autologous tumor stimulation and interleukin 2.
J Neurooncol. 1986;4(1):55-64. doi: 10.1007/BF02158003.
7
Lysis of autologous tumor cells by blood lymphocytes tested at the time of surgery. Correlation with the postsurgical clinical course.手术时检测血液淋巴细胞对自体肿瘤细胞的溶解作用。与术后临床病程的相关性。
Cancer Immunol Immunother. 1986;21(1):69-76. doi: 10.1007/BF00199380.
8
Proliferative response of lymphocytes from ovarian cancer patients to autologous tumor cells.卵巢癌患者淋巴细胞对自体肿瘤细胞的增殖反应。
Cancer Immunol Immunother. 1988;27(1):69-76. doi: 10.1007/BF00205761.
9
Lysis of autologous tumor cells by blood lymphocytes activated in autologous mixed lymphocyte tumor cell culture--no correlation with the postsurgical clinical course.自体混合淋巴细胞肿瘤细胞培养中激活的血液淋巴细胞对自体肿瘤细胞的溶解作用——与术后临床病程无关。
Cancer Immunol Immunother. 1987;24(2):180-3. doi: 10.1007/BF00205598.
10
Proliferative and cytotoxic responses of human peripheral blood lymphocytes to autologous malignant effusions. An analysis at the clonal level.人外周血淋巴细胞对自体恶性积液的增殖和细胞毒性反应。克隆水平分析。
Cancer Immunol Immunother. 1986;22(2):107-13. doi: 10.1007/BF00199123.
本文引用的文献
1
Osteosarcoma. A review of 96 cases.骨肉瘤。96例病例回顾。
Acta Radiol (Stockh). 1961 Jul;56:1-19.
2
Specific and non-specific lymphocyte cytotoxicity in colon carcinoma.结肠癌中的特异性和非特异性淋巴细胞细胞毒性
Br J Cancer. 1981 Dec;44(6):846-55. doi: 10.1038/bjc.1981.283.
3
Separation and characteristics of tumor-infiltrating lymphocytes in man.人类肿瘤浸润淋巴细胞的分离与特性
Contemp Top Immunobiol. 1980;10:79-107. doi: 10.1007/978-1-4684-3677-8_4.
4
The prognosis in osteosarcoma: Norwegian National Data.骨肉瘤的预后：挪威国家数据。
Cancer. 1981 Oct 15;48(8):1719-23. doi: 10.1002/1097-0142(19811015)48:8<1719::aid-cncr2820480806>3.0.co;2-j.
5
Can historical controls be used in current clinical trials in osteosarcoma?. Metastases and survival in a historical and a concurrent group.骨肉瘤当前的临床试验中能否使用历史对照？历史组与同期组的转移情况和生存率。
Int J Radiat Oncol Biol Phys. 1980 Dec;6(12):1717-21. doi: 10.1016/0360-3016(80)90258-8.
6
Human T lymphocyte subpopulations defined by Fc receptors and monoclonal antibodies. A comparison.由Fc受体和单克隆抗体定义的人T淋巴细胞亚群。一项比较。
J Exp Med. 1980 Apr 1;151(4):969-74. doi: 10.1084/jem.151.4.969.
7
Specificity of auto-tumor cytotoxicity exerted by fresh, activated and propagated human T lymphocytes.新鲜、活化及增殖的人T淋巴细胞产生的自身肿瘤细胞毒性的特异性
Int J Cancer. 1982 May 15;29(5):547-53. doi: 10.1002/ijc.2910290510.
8
Osteogenic sarcoma. A study of six hundred cases.骨肉瘤。六百例病例的研究。
J Bone Joint Surg Am. 1967 Jan;49(1):101-10.
9
Soft part sarcomas revisited. Review and comparison of a second series.软组织肉瘤再探讨。第二组病例的回顾与比较。
Cancer. 1972 Aug;30(2):475-80. doi: 10.1002/1097-0142(197208)30:2<475::aid-cncr2820300227>3.0.co;2-p.
10
Stimulation of lymphocytes by autochthonous cancer.自体肿瘤对淋巴细胞的刺激。
Natl Cancer Inst Monogr. 1972 Dec;35:237-42.
Zotero 插件