宫颈癌原位癌和浸润癌阶段针对宫颈癌细胞系的抗体及细胞免疫反应发生率的差异。
Divergence between the occurrence of antibody and cellular immune reactivity to cervical carcinoma cell lines in preinvasive and macroinvasive stages of cervical carcinoma.
作者信息
van de Linde A W, Streefkerk M, Schuurman H J, te Velde E R, Kater L
出版信息
Br J Cancer. 1983 Jan;47(1):147-53. doi: 10.1038/bjc.1983.17.
A lymphocyte stimulation assay is described which detects immune reactivity to antigens derived from the CaSki cervical carcinoma cell line. Taking a stimulation index of greater than 4.1 as positive, the peripheral blood lymphocytes of 14/20 patients (70%) with untreated dysplasia or carcinoma-in-situ, 8/19 patients (42%) with untreated macroinvasive squamous cell carcinoma of the uterine cervix and 8/38 controls (21%) showed positive reactions. Statistical analysis revealed a significant difference between the group of patients with dysplasia or carcinoma-in-situ and the controls. The sera of patients and controls were simultaneously tested for the presence of tumour-directed antibody. There was no correlation between the occurrence of cellular immune reactivity and of serum antibody, both directed to cervical carcinoma antigens. Cellular immune reactivity tended to occur more frequently in patients with preinvasive stages of cervical carcinoma, and serum antibody in patients with macroinvasive carcinoma.
描述了一种淋巴细胞刺激试验，该试验可检测针对源自CaSki宫颈癌细胞系的抗原的免疫反应性。以大于4.1的刺激指数为阳性，14/20例（70%）未经治疗的发育异常或原位癌患者、8/19例（42%）未经治疗的子宫颈大浸润性鳞状细胞癌患者和8/38例对照者（21%）的外周血淋巴细胞显示出阳性反应。统计分析显示，发育异常或原位癌患者组与对照组之间存在显著差异。同时检测患者和对照者血清中肿瘤定向抗体的存在。针对宫颈癌抗原的细胞免疫反应性和血清抗体的出现之间没有相关性。细胞免疫反应性在宫颈癌浸润前期患者中更频繁出现，而血清抗体在大浸润性癌患者中更常见。
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