Cummings R H
Magellan Laboratories Incorporated, Morrisville, NC, USA.
J Allergy Clin Immunol. 1999 Dec;104(6):S230-6. doi: 10.1016/s0091-6749(99)70036-9.
This article reviews the issues related to the performance of valves in metered dose inhalers with respect to chlorofluorocarbon propellant replacement. Reformulation of existing chlorofluorocarbon-based products with hydrofluoroalkane propellants has been a much more difficult task than initially anticipated, complicated by the need to concurrently develop better performing valves with cleaner extractive profiles. This paper will examine issues related to the reformulation and development of new valves and the tests and procedures used to evaluate valve performance. Evaluation of valve performance will consider the tests performed: mechanisms by which valves fail and analytic testing errors that can complicate the interpretation of results.
本文回顾了与计量吸入器中阀门在氯氟烃推进剂替代方面的性能相关的问题。用氢氟烷烃推进剂对现有的基于氯氟烃的产品进行重新配方设计，一直是一项比最初预期困难得多的任务，由于需要同时开发具有更清洁萃取特性且性能更优的阀门，这一任务变得更加复杂。本文将探讨与新阀门的重新配方设计和开发相关的问题，以及用于评估阀门性能的测试和程序。阀门性能评估将考虑所进行的测试：阀门失效的机制以及可能使结果解释复杂化的分析测试误差。
