Talsma E, Goettsch W G, Nieste H L, Schrijnemakers P M, Sprenger M J
Department of Infectious Diseases Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands.
Clin Infect Dis. 1999 Oct;29(4):845-8. doi: 10.1086/520447.
To identify epidemiological features of culture-proven campylobacter infections and to determine resistance rates, we conducted a 4-year demographic survey of culture-proven campylobacteriosis in one Dutch region. Examination of 24,435 fecal specimens revealed 1,315 cases of campylobacteriosis (5.4%). The ofloxacin-resistance rate among Campylobacter isolates increased from 11% to 29%. Resistance against tetracycline fluctuated between 7% and 15%, and resistance against erythromycin remained low. Resistance against fluoroquinolones was seasonally influenced, with relatively high rates during winter. We conclude that resistance of Campylobacter isolates to fluoroquinolones is still rising, probably because of the use of fluoroquinolones (enrofloxacin) in animal husbandry.
为了确定经培养证实的弯曲杆菌感染的流行病学特征并测定耐药率，我们在荷兰的一个地区开展了一项为期4年的经培养证实的弯曲杆菌病的人口统计学调查。对24435份粪便标本进行检测，发现1315例弯曲杆菌病（5.4%）。弯曲杆菌分离株对氧氟沙星的耐药率从11%升至29%。对四环素的耐药率在7%至15%之间波动，对红霉素的耐药率仍然较低。对氟喹诺酮类药物的耐药受季节影响，冬季耐药率相对较高。我们得出结论，弯曲杆菌分离株对氟喹诺酮类药物的耐药性仍在上升，这可能是由于畜牧业中使用氟喹诺酮类药物（恩诺沙星）所致。
