Koudstaal J, Van Dop P A, Hogerzeil H V, Kremer J A, Naaktgeboren N, Van Os H C, Tiemessen C H, Visser G H
Afd. Gynaecologie en Verloskunde, Universitair Medisch Centrum Utrecht.
Ned Tijdschr Geneeskd. 1999 Nov 20;143(47):2375-80.
Description of the outcome of pregnancies after in vitro fertilisation (IVF) in Dutch IVF centers.
Descriptive, retrospective.
Data were collected on IVF pregnancies in the period 1984-1992 from seven Dutch IVF centers.
The study comprised 2956 pregnancies. Five centres provided data on 2133 ongoing and non-ongoing pregnancies. More than 25% ended in a spontaneous abortion (22.3%) or ectopic pregnancy (3.6%). From the seven centres there were data available on 2311 ongoing pregnancies. Of these, 30.8% were multiple; preterm delivery occurred in 29.2%. The birth weight of 40.6% of 3173 neonates was lower than 2500 g and that of 10.1% lower than 1500 g. A birth weight under the 10th percentile of the national reference curve was found in 16.7% and under the 2.3rd percentile in 4.3% of cases. Perinatal mortality was 31.3 pro mille. In 1588 singleton pregnancies preterm birth occurred in 15.6%; 41.3% of the singletons weighed less than 2500 g, of which 3.6% less than 1500 g while 12.3% had a birth weight below the 10th percentile. The results of our study are similar to those of other major studies in the literature and are unfavourable compared with to Dutch reference values. This is mainly due to the high proportion of multiple pregnancies. However, we found indications of a slight disturbance of pregnancy in IVF singleton and twin pregnancies.
描述荷兰体外受精（IVF）中心体外受精后妊娠的结局。
描述性、回顾性研究。
收集了1984年至1992年期间荷兰7个体外受精中心的体外受精妊娠数据。
该研究包括2956例妊娠。5个中心提供了2133例持续和非持续妊娠的数据。超过25%的妊娠以自然流产（22.3%）或异位妊娠（3.6%）告终。7个中心提供了2311例持续妊娠的数据。其中，30.8%为多胎妊娠；早产发生率为29.2%。3173例新生儿中，40.6%的出生体重低于2500克，10.1%的出生体重低于1500克。16.7%的病例出生体重低于全国参考曲线的第10百分位数，4.3%的病例低于第2.3百分位数。围产期死亡率为31.3‰。在1588例单胎妊娠中，早产发生率为15.6%；41.3%的单胎体重低于2500克，其中3.6%低于1500克，12.3%的出生体重低于第10百分位数。我们的研究结果与文献中其他主要研究的结果相似，与荷兰参考值相比并不理想。这主要是由于多胎妊娠的比例较高。然而，我们发现体外受精单胎和双胎妊娠中存在轻微妊娠紊乱的迹象。
