Verlaenen H, Cammu H, Derde M P, Amy J J
Department of Gynecology and Obstetrics, Academisch Ziekenhuis VUB, Brussels, Belgium.
Obstet Gynecol. 1995 Dec;86(6):906-10. doi: 10.1016/0029-7844(95)00322-I.
To determine if singleton in vitro fertilization (IVF) pregnancies carry a higher risk for ante- and perinatal complications compared with naturally conceived pregnancies.
One hundred forty singleton pregnancies conceived by IVF and 140 matched control pregnancies conceived naturally were analyzed with respect to the incidence of antepartum complications and perinatal outcome. The study was conducted in a university hospital, and pregnancy and labor were managed according to a standardized protocol.
Sixteen IVF pregnancies and two control pregnancies ended preterm (P < .01), resulting in the birth of infants with lower birth weight in the former group (P = .01). Except for placenta previa, which occurred four times in IVF pregnancies and not in the control group, no differences in antenatal events were found. Labor was more often induced in IVF pregnancies than in control pregnancies. Elective cesarean delivery for obstetric reasons was performed ten times in the IVF group and never in the controls (P < .01). However, once in labor, no differences in the rate of instrumental or cesarean delivery were found. There were eight minor congenital malformations in the IVF group and none in the control group (P < .01).
Even when managed in a single center, IVF pregnancies carry a greater antenatal risk than matched controls. Once in labor, and managed in a similar fashion, the outcome does not differ from that of controls.
确定与自然受孕的妊娠相比，单胎体外受精（IVF）妊娠是否具有更高的产前和围产期并发症风险。
分析了140例通过IVF受孕的单胎妊娠和140例与之匹配的自然受孕对照妊娠的产前并发症发生率和围产期结局。该研究在一家大学医院进行，妊娠和分娩按照标准化方案进行管理。
16例IVF妊娠和2例对照妊娠早产（P <.01），导致前一组出生的婴儿出生体重较低（P =.01）。除前置胎盘外，IVF妊娠中发生4次，对照组未发生，产前事件未发现差异。IVF妊娠比对照妊娠更常引产。因产科原因择期剖宫产在IVF组进行了10次，对照组从未进行过（P <.01）。然而，一旦进入分娩期，器械助产或剖宫产率未发现差异。IVF组有8例轻微先天性畸形，对照组无（P <.01）。
即使在单一中心进行管理，IVF妊娠的产前风险也高于匹配的对照组。一旦进入分娩期并以类似方式管理，结局与对照组无差异。
