血清碱性磷酸酶骨同工酶活性与代谢性及肿瘤性骨病中尿羟脯氨酸排泄的关系。
Relationship of the activity of the bone isoenzyme of serum alkaline phosphatase to urinary hydroxyproline excretion in metabolic and neoplastic bone diseases.
作者信息
Stĕpán J, Pacovský V, Horn V, Silinková-Málková E, Vokrouhlická O, Konopásek B, Formánková J, Hrba J, Marek J
出版信息
Eur J Clin Invest. 1978 Dec;8(6):373-7. doi: 10.1111/j.1365-2362.1978.tb00867.x.
A significant correlation between the activity of the bone isoenzyme or serum alkaline phosphatase and the urinary hydroxyproline excretion in osteomalacia, osteoporosis, primary hyperparathyroidism with osteodystrophy, Paget's disease, secondary bone tumours, and in a control group was found (P less than 0.001). This close correlation was not observed between these variables in patients with active acromegaly. Diagnosis determined from these indices of formation and turnover of bone matrix agreed with that established by histological and histochemical examination of bone, by X-ray investigation of the skeleton, and by the radionuclear 85Sr test. The relationship between the activity of bone isoenzyme and urinary hydroxyproline excretion differed in metabolic bone diseases with a high bone turnover, in patients with osteoporosis and in patients with early osteoclastic bone metastases.
在骨软化症、骨质疏松症、伴有骨营养不良的原发性甲状旁腺功能亢进、佩吉特病、继发性骨肿瘤患者以及对照组中，发现骨同工酶或血清碱性磷酸酶的活性与尿羟脯氨酸排泄之间存在显著相关性（P小于0.001）。在活动性肢端肥大症患者中，未观察到这些变量之间的这种密切相关性。根据这些骨基质形成和转换指标做出的诊断与通过骨组织学和组织化学检查、骨骼X线检查以及放射性核素85Sr试验所确定的诊断一致。在高骨转换的代谢性骨病、骨质疏松症患者以及早期破骨性骨转移患者中，骨同工酶活性与尿羟脯氨酸排泄之间的关系有所不同。
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