Wooldridge D E
Proc Natl Acad Sci U S A. 1975 Sep;72(9):3468-71. doi: 10.1073/pnas.72.9.3468.
A model of the neural membrane is described, based on a set of "convertible gates" on its inner surface. The atomic arrangement of a gate is specified to be subject to modification by a set of chemical reactions, sometimes permitting sodium ions, sometimes potassium ions, sometimes neither, to have access to the transmembrane channel it guards. Reaction rate and current/voltage equations are developed, values assigned to the parameters, and computer solutions obtained. Under pulse or continuous stimulating current the model is found to generate action potential spikes closely similar in height and shape to those of real neurons. Other electrical properties are also relatively neuron-like.
本文描述了一种基于神经膜内表面一组“可转换门控”的神经膜模型。门控的原子排列被设定为可通过一组化学反应进行修饰，有时允许钠离子，有时允许钾离子，有时两者都不允许进入其守护的跨膜通道。推导了反应速率以及电流/电压方程，为参数赋值，并获得了计算机解决方案。发现在脉冲或连续刺激电流下，该模型产生的动作电位尖峰在高度和形状上与真实神经元的非常相似。其他电学特性也相对类似神经元。
