动作电位的分子模型。
A molecular model of action potentials.
作者信息
Dubois D M, Schoffeniels E
出版信息
Proc Natl Acad Sci U S A. 1974 Jul;71(7):2858-62. doi: 10.1073/pnas.71.7.2858.
Abstract
A QUANTITATIVELY CONSISTENT MODEL OF NERVE ACTIVITY IS GIVEN IN TERMS OF TWO MAIN BIOCHEMICAL CYCLES NARROWLY INTERLOCKED
an acetylcholine cycle and a calcium cycle. The activity of both cycles is controlled among other things by the electric field and various allosteric effectors. As shown by digital simulations our model accounts for the basic properties of an action potential as described by the electrophysiologists. Thus the shape, time course, and behavior under voltage clamping conditions of both sodium and potassium permeability variations are adequately reproduced.
摘要
根据紧密相连的两个主要生化循环
乙酰胆碱循环和钙循环，给出了一个神经活动的定量一致模型。这两个循环的活动除其他因素外还受电场和各种别构效应物的控制。如数字模拟所示，我们的模型解释了电生理学家所描述的动作电位的基本特性。因此，钠和钾通透性变化在电压钳制条件下的形状、时间进程和行为都得到了充分再现。
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1
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J Physiol. 1952 Apr;116(4):497-506. doi: 10.1113/jphysiol.1952.sp004719.
2
THE ADENOSINE-TRIPHOSPHATASE SYSTEM RESPONSIBLE FOR CATION TRANSPORT IN ELECTRIC ORGAN: EXCLUSION OF PHOSPHOLIPIDS AS INTERMEDIATES.负责电鳐电器官中阳离子转运的三磷酸腺苷酶系统：排除磷脂作为中间产物。
Biochem J. 1965 Mar;94(3):692-9. doi: 10.1042/bj0940692.
3
Ionic movements and electrical activity in giant nerve fibres.巨神经纤维中的离子运动与电活动。
Proc R Soc Lond B Biol Sci. 1958 Jan 1;148(930):1-37. doi: 10.1098/rspb.1958.0001.
4
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J Physiol. 1952 Aug;117(4):500-44. doi: 10.1113/jphysiol.1952.sp004764.
5
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Life Sci. 1970 Mar 1;9(5):259-67. doi: 10.1016/0024-3205(70)90027-5.
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J Theor Biol. 1974 Jan;43(1):65-72. doi: 10.1016/s0022-5193(74)80045-7.
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