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动作电位的分子模型。

A molecular model of action potentials.

作者信息

Dubois D M, Schoffeniels E

出版信息

Proc Natl Acad Sci U S A. 1974 Jul;71(7):2858-62. doi: 10.1073/pnas.71.7.2858.

DOI:10.1073/pnas.71.7.2858
PMID:4527609
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC388571/
Abstract

A QUANTITATIVELY CONSISTENT MODEL OF NERVE ACTIVITY IS GIVEN IN TERMS OF TWO MAIN BIOCHEMICAL CYCLES NARROWLY INTERLOCKED

an acetylcholine cycle and a calcium cycle. The activity of both cycles is controlled among other things by the electric field and various allosteric effectors. As shown by digital simulations our model accounts for the basic properties of an action potential as described by the electrophysiologists. Thus the shape, time course, and behavior under voltage clamping conditions of both sodium and potassium permeability variations are adequately reproduced.

摘要

根据紧密相连的两个主要生化循环

乙酰胆碱循环和钙循环，给出了一个神经活动的定量一致模型。这两个循环的活动除其他因素外还受电场和各种别构效应物的控制。如数字模拟所示，我们的模型解释了电生理学家所描述的动作电位的基本特性。因此，钠和钾通透性变化在电压钳制条件下的形状、时间进程和行为都得到了充分再现。

相似文献

1
A molecular model of action potentials.动作电位的分子模型。
Proc Natl Acad Sci U S A. 1974 Jul;71(7):2858-62. doi: 10.1073/pnas.71.7.2858.
2
Molecular model of postsynaptic potential.突触后电位的分子模型。
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Spike-forming model of neural membrane: computer simulation of additional perfused axon experiments.神经膜的锋电位形成模型：附加灌流轴突实验的计算机模拟
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Towards a molecular theory of the nerve membrane.
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[Voltage-dependent ion channels of the somatic membrane of nerve cells].[神经细胞体膜的电压依赖性离子通道]
Fiziol Zh (1978). 1984 May-Jun;30(3):267-77.
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Stimulation of membrane properties.膜特性的刺激。
Biomembranes. 1972;3:449-71.
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Towards a physical understanding of physiological excitation as a cooperative specific adsorption phenomenon.从物理角度理解生理兴奋作为一种协同特异性吸附现象。
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Simulation of action potential damping produced by anticonvulsant drugs.抗惊厥药物产生的动作电位衰减模拟。
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[Electrotropic acetylcholine action on the mammalian auricle by means of the "phase plane" trajectories of the action potential].[通过动作电位的“相平面”轨迹研究电致乙酰胆碱对哺乳动物耳廓的作用]
Acta Biol Med Ger. 1979;38(7):987-98.
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[Ionic mechanisms of autorhythmic activity (a study of mathematical models of excitable membranes)].[自动节律性活动的离子机制（可兴奋膜数学模型的研究）]
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A spike-forming model of the neural membrane.神经膜的一个形成尖峰的模型。
Proc Natl Acad Sci U S A. 1975 Sep;72(9):3468-71. doi: 10.1073/pnas.72.9.3468.
5
Molecular model of postsynaptic potential.突触后电位的分子模型。
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6
Physical-chemical approach to the transient change in Na ion conductivity of excitable membranes.可兴奋膜钠离子电导率瞬态变化的物理化学方法。
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Molecular events and energy changes during the action potential.动作电位期间的分子事件和能量变化。
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本文引用的文献

1
The dual effect of membrane potential on sodium conductance in the giant axon of Loligo.枪乌贼巨大轴突中膜电位对钠电导的双重作用。
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Inhibition of membrane-bound acetylcholinesterase by d-tubocurarine and its reversal by bivalent cations.
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On the molecular mechanism of action of scorpion neurotoxin. II. From Androctonus australis Hector.关于蝎子神经毒素的分子作用机制。II. 来自澳大利亚杀人蝎（澳毒蝎）。
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An attempt at an integral interpretation of nerve excitability.对神经兴奋性进行整体解释的一次尝试。
Proc Natl Acad Sci U S A. 1973 Mar;70(3):727-31. doi: 10.1073/pnas.70.3.727.
8
Long-lived conformation changes induced by electric impulses in biopolymers.生物聚合物中电脉冲诱导的长寿命构象变化。
Proc Natl Acad Sci U S A. 1972 Apr;69(4):993-7. doi: 10.1073/pnas.69.4.993.
9
[Contribution to the study of the allosteric properties of acetylcholinesterase].[对乙酰胆碱酯酶变构特性的研究贡献]
Arch Int Physiol Biochim. 1970 Apr;78(2):259-64. doi: 10.3109/13813457009103801.
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[Allosterism and permeability of cell membranes].[变构作用与细胞膜通透性]
Arch Int Physiol Biochim. 1970 Apr;78(2):205-23. doi: 10.3109/13813457009103798.