Bateman A, Birney E, Durbin R, Eddy S R, Howe K L, Sonnhammer E L
The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Nucleic Acids Res. 2000 Jan 1;28(1):263-6. doi: 10.1093/nar/28.1.263.
Pfam is a large collection of protein multiple sequence alignments and profile hidden Markov models. Pfam is available on the WWW in the UK at http://www.sanger.ac.uk/Software/Pfam/, in Sweden at http://www.cgr.ki.se/Pfam/ and in the US at http://pfam.wustl.edu/. The latest version (4.3) of Pfam contains 1815 families. These Pfam families match 63% of proteins in SWISS-PROT 37 and TrEMBL 9. For complete genomes Pfam currently matches up to half of the proteins. Genomic DNA can be directly searched against the Pfam library using the Wise2 package.
Pfam是一个蛋白质多序列比对和轮廓隐马尔可夫模型的大型集合。Pfam可通过以下网址在网上获取:英国的http://www.sanger.ac.uk/Software/Pfam/,瑞典的http://www.cgr.ki.se/Pfam/,以及美国的http://pfam.wustl.edu/。Pfam的最新版本(4.3)包含1815个家族。这些Pfam家族与SWISS-PROT 37和TrEMBL 9中63%的蛋白质相匹配。对于完整基因组,Pfam目前能匹配多达一半的蛋白质。可以使用Wise2软件包直接针对Pfam库搜索基因组DNA。