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Pfam 3.1：1313个多重比对和隐马尔可夫模型概况与大多数蛋白质匹配。

Pfam 3.1: 1313 multiple alignments and profile HMMs match the majority of proteins.

作者信息

Bateman A, Birney E, Durbin R, Eddy S R, Finn R D, Sonnhammer E L

机构信息

The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

出版信息

Nucleic Acids Res. 1999 Jan 1;27(1):260-2. doi: 10.1093/nar/27.1.260.

DOI:10.1093/nar/27.1.260
PMID:9847196
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC148151/
Abstract

Pfam is a collection of multiple alignments and profile hidden Markov models of protein domain families. Release 3.1 is a major update of the Pfam database and contains 1313 families which are available on the World Wide Web in Europe at http://www.sanger.ac.uk/Software/Pfam/ and http://www.cgr.ki.se/Pfam/, and in the US at http://pfam.wustl.edu/. Over 54% of proteins in SWISS-PROT-35 and SP-TrEMBL-5 match a Pfam family. The primary changes of Pfam since release 2.1 are that we now use the more advanced version 2 of the HMMER software, which is more sensitive and provides expectation values for matches, and that it now includes proteins from both SP-TrEMBL and SWISS-PROT.

摘要

Pfam是蛋白质结构域家族的多序列比对和隐马尔可夫模型概况的集合。3.1版是Pfam数据库的一次重大更新，包含1313个家族，可在欧洲通过万维网访问，网址为http://www.sanger.ac.uk/Software/Pfam/和http://www.cgr.ki.se/Pfam/，在美国可通过http://pfam.wustl.edu/访问。SWISS-PROT-35和SP-TrEMBL-5中超过54%的蛋白质与Pfam家族匹配。自2.1版发布以来，Pfam的主要变化在于，我们现在使用了更先进的HMMER软件版本2，该版本更敏感，并能为匹配提供期望值，而且现在它包含了来自SP-TrEMBL和SWISS-PROT的蛋白质。

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