Périer R C, Praz V, Junier T, Bonnard C, Bucher P
Swiss Institute of Bioinformatics and Swiss Institute for Experimental Cancer Research, Ch. des Boveresses 155, 1066-Epalinges s/Lausanne, Switzerland.
Nucleic Acids Res. 2000 Jan 1;28(1):302-3. doi: 10.1093/nar/28.1.302.
The Eukaryotic Promoter Database (EPD) is an annotated non-redundant collection of eukaryotic POL II promoters for which the transcription start site has been determined experimentally. Access to promoter sequences is provided by pointers to positions in nucleotide sequence entries. The annotation part of an entry includes a description of the initiation site mapping data, exhaustive cross-references to the EMBL nucleotide sequence database, SWISS-PROT, TRANSFAC and other databases, as well as bibliographic references. EPD is structured in a way that facilitates dynamic extraction of biologically meaningful promoter subsets for comparative sequence analysis. WWW-based interfaces have been developed that enable the user to view EPD entries in different formats, to select and extract promoter sequences according to a variety of criteria, and to navigate to related databases exploiting different cross-references. The EPD web site also features yearly updated base frequency matrices for major eukaryotic promoter elements. EPD can be accessed at http://www.epd.isb-sib.ch
真核生物启动子数据库(EPD)是一个经过注释的非冗余真核生物聚合酶II启动子集合,其转录起始位点已通过实验确定。通过指向核苷酸序列条目中的位置指针来提供对启动子序列的访问。条目的注释部分包括起始位点定位数据的描述、与EMBL核苷酸序列数据库、SWISS-PROT、TRANSFAC和其他数据库的详尽交叉引用,以及参考文献。EPD的结构便于动态提取具有生物学意义的启动子子集以进行比较序列分析。已经开发了基于万维网的界面,使用户能够以不同格式查看EPD条目,根据各种标准选择和提取启动子序列,并利用不同的交叉引用导航到相关数据库。EPD网站还提供主要真核生物启动子元件的年度更新碱基频率矩阵。可通过http://www.epd.isb-sib.ch访问EPD