Cernéa P, Szpirglas H, Teboul L
Rev Stomatol Chir Maxillofac. 1975 Jul-Aug;76(5):397-404.
Long-term use of corticoids had proved beneficial in the treatment of advanced stomatological cancers, the effective dose being 40 mg of prednisone per day. In so far as it is possible to distinguish any specific action on individual symptoms, its action on pain was obvious in 40% of cases, on inflammation and infection in 52% of cases on fever (independent of infection) in 14% of cases, on oedema in 34% of cases. It was almost invariably favourable on the general condition. The method of using it emphasize how easy it is to use corticoids by injection which is of particular value in our speciality in view of: dysphagia, administration of large doses, deficiencies in the general condition, sometimes a matter of urgency. The counter-indications usually recognized for corticoids need to be modified in the case of cancer patients. Incidents occur surprisingly rarely and are minor relative to the advantages of the therapy, provided the patient is kept under strict supervision.
长期使用皮质类固醇已被证明对晚期口腔癌的治疗有益,有效剂量为每日40毫克泼尼松。就其对个体症状的任何特定作用而言,其对疼痛的作用在40%的病例中明显,对炎症和感染的作用在52%的病例中明显,对发热(与感染无关)的作用在14%的病例中明显,对水肿的作用在34%的病例中明显。它几乎总是对一般状况有利。其使用方法强调了通过注射使用皮质类固醇是多么容易,鉴于吞咽困难、大剂量给药、一般状况不佳,有时甚至是紧急情况,这在我们这个专业中具有特殊价值。对于癌症患者,通常公认的皮质类固醇禁忌证需要加以调整。只要对患者进行严格监督,意外情况出人意料地很少发生,而且相对于治疗的益处来说是轻微的。