Nisell H, Erikssen C, Persson B, Carlström K
Department of Obstetrics and Gynaecology and Clinical Research Center Huddinge, Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden.
Gynecol Obstet Invest. 1999;48(4):241-6. doi: 10.1159/000010191.
To compare women after a preeclamptic pregnancy with women after a normal pregnancy with respect to androgenic-anabolic status and carbohydrate and lipid profiles.
Twenty-one patients and 22 controls were followed up to 26-119 weeks after delivery. Blood was sampled for analyses of insulin, glucose, insulin growth factor-1, lipids, androgens, sex hormone-binding globulin (SHBG) and uric acid. Anthropometric data and blood pressure were recorded. Data are presented as median and ranges (within parentheses) or mean +/- SEM where appropriate. Comparisons were made by unpaired t test or Mann-Whitney U test, respectively.
Significantly higher values were found in the preeclampsia than in the control group for fasting insulin, fasting glucose, fasting insulin resistance index (FIRI, fasting glucose x fasting insulin/25), serum triglycerides, uric acid and blood pressure. There were no differences in androgen status and IGF-1 levels.
Patients with a recent history of preeclampsia demonstrate signs of relative insulin resistance, hypertriglyceridemia and hyperuricemia as well as increased blood pressure as compared with women who had a normal pregnancy. However, in contrast to other women with insulin resistance, they have a normal androgen status.
比较子痫前期妊娠后的女性与正常妊娠后的女性在雄激素合成代谢状态以及碳水化合物和脂质谱方面的情况。
对21例患者和22例对照者进行产后26 - 119周的随访。采集血液样本以分析胰岛素、葡萄糖、胰岛素生长因子-1、脂质、雄激素、性激素结合球蛋白（SHBG）和尿酸。记录人体测量数据和血压。数据以中位数和范围（括号内）表示，或在适当情况下以平均值±标准误表示。分别采用非配对t检验或曼-惠特尼U检验进行比较。
子痫前期组的空腹胰岛素、空腹血糖、空腹胰岛素抵抗指数（FIRI，空腹血糖×空腹胰岛素/25）、血清甘油三酯、尿酸和血压值显著高于对照组。雄激素状态和IGF-1水平无差异。
与正常妊娠的女性相比，近期有子痫前期病史的患者表现出相对胰岛素抵抗、高甘油三酯血症和高尿酸血症的迹象，以及血压升高。然而，与其他胰岛素抵抗的女性不同，她们的雄激素状态正常。
