Saïd S, Nevez G, Morinière P, Fournier A, Raccurt C P
Service de néphrologie, Centre hospitalier Universitaire d'Amiens.
Nephrologie. 1999;20(6):343-6.
The authors report a case of recurrent strongyloidiasis in a former French soldier of the Indochina colonial war (1946-54). Strongyloidiasis was associated with inaugural renal failure (acute steroid-resistant interstitial-type), requiring permanent hemodialysis. Despite antiparasitic treatment, relapse with digestive and pulmonary symptoms occurred 10 years later, following chronic eosinophilia. This observation emphasises that in dialysed subjects, eosinophilia should always stimulate a search for parasitic etiologies before incriminating dialysis-material allergy. Strongyloidiasis is a self-perpetuating helminthiasis whose distribution area is far greater than the intertropical zone. It can be completely asymptomatic, appear as late digestive complications and be responsible for bacteraemic peaks with septic visceral localizations. It causes a chronic oscillating eosinophilia. Diagnosis is usually performed by iterative stool examinations by Baermann technique in order to detect Strongyloides stercoralis rhabditoid larvae. In dialysed patients with unexplained eosinophilia awaiting renal transplant, the options of systematic thiabendazole (50 mg/kg) or ivermectine (0.2 mg/kg) single-dose to overcame the risk of disseminated strongyloidiasis induced by immunosuppressive post-transplantation therapy could be debated.
作者报告了一例曾参加印度支那殖民战争(1946 - 1954年)的法国退伍军人复发性类圆线虫病病例。类圆线虫病伴有首发肾衰竭(急性类固醇抵抗性间质性类型),需要长期血液透析。尽管进行了抗寄生虫治疗,但在慢性嗜酸性粒细胞增多症出现10年后,仍出现了伴有消化和肺部症状的复发。该观察结果强调,在透析患者中,嗜酸性粒细胞增多症在归咎于透析材料过敏之前,应始终促使寻找寄生虫病因。类圆线虫病是一种自身传播的蠕虫病,其分布区域远大于热带地区。它可能完全无症状,表现为晚期消化并发症,并导致伴有感染性内脏定位的菌血症高峰。它会引起慢性波动性嗜酸性粒细胞增多症。诊断通常通过采用贝曼技术反复进行粪便检查来检测粪类圆线虫杆状蚴。对于等待肾移植且嗜酸性粒细胞增多原因不明的透析患者,系统性使用噻苯达唑(50 mg/kg)或单剂量伊维菌素(0.2 mg/kg)以克服移植后免疫抑制治疗引起播散性类圆线虫病风险的选择可能存在争议。