Fasanmade A A
Department of Physiology, College of Medicine, University of Ibadan, Nigeria.
West Afr J Med. 1999 Jul-Sep;18(3):183-6.
To determine the effect of diuretic therapy on osmotic fragility of red blood cells of hypertensive patients, 25 hypertensive and 15 normotensive subjects were followed up for 12 weeks. Osmotic fragility of erythrocytes of the hypertensive subjects were determined before treatment and at 6 weeks and 12 weeks after the start of diuretic therapy. The red cell size was larger in hypertensive subjects than in normal controls. With treatment, however, the red cell size was similar in the two groups of subjects. Osmotic fragility was higher in hypertensive subjects than in normotensive subjects. The osmotic fragility also became similar in the two groups with control of blood pressure in the hypertensive group. Osmotic fragility of red blood cells may be determined as a screening tool for hypertensive patients who will benefit from diuretic therapy.
为了确定利尿疗法对高血压患者红细胞渗透脆性的影响，对25名高血压患者和15名血压正常者进行了为期12周的随访。在利尿疗法开始前以及开始治疗后6周和12周测定高血压患者红细胞的渗透脆性。高血压患者的红细胞大小比正常对照组大。然而，经过治疗，两组受试者的红细胞大小相似。高血压患者的渗透脆性高于血压正常者。随着高血压组血压得到控制，两组的渗透脆性也变得相似。红细胞渗透脆性可作为筛选能从利尿疗法中获益的高血压患者的一种工具。
