Gaikwad S S, Avari J G
Department of Pharmaceutical Sciences, R. T. M. Nagpur University, Mahatma, Jyotiba Fuley Educational Campus, Amravati Road, Nagpur, 440033, Maharashtra. India.
Curr Hypertens Rev. 2017;13(2):132-137. doi: 10.2174/1573402113666170911140747.
Hypertension is a common health problem concerning a large proportion of population and a leading global risk factor for the burden of cardiovascular disease (CVD). The purpose of this study was to assess the efficacy of the erythrocyte zeta potential as a potential additional indicator for cardiovascular disorder risk so that patients with this can be more rapidly identified and treated.
In the present study, blood samples were collected in 5% dextrose solution from patients suffering from hypertension and healthy volunteers (Not taken any medication). The mobility of individual RBCs was tracked by equipped Zeta meter-ZM4DAQ software using microscopicallyacquired video images, data were recorded 10 times for each sample and average zeta-potential in mv was recorded.
We found that mean erythrocytic ZP of control group was found to be 23.41 mv (± 1.87) whereas, erythrocytic ZP for Hypertensive patients was found to be 16.05 (±1.72) mV and Hypertensive patients with Diabetes is much lower from 6.96 mV to 22.76 (+3.88) mV along with structural deformities and increased osmotic fragility of erythrocytes.
The data suggest that there are morphological changes in erythrocyte structure, increased osmotic fragility along with significantly lower ZP value as compared to that of healthy volunteers which may be the major cause for progression to the development of cardiovascular disease.
高血压是一个涉及很大比例人群的常见健康问题，也是全球心血管疾病（CVD）负担的主要风险因素。本研究的目的是评估红细胞zeta电位作为心血管疾病风险潜在附加指标的有效性，以便能更快速地识别和治疗患有该疾病的患者。
在本研究中，从高血压患者和健康志愿者（未服用任何药物）中采集置于5%葡萄糖溶液中的血样。使用配备的Zeta meter-ZM4DAQ软件通过显微镜获取的视频图像跟踪单个红细胞的迁移率，每个样本记录10次数据，并记录以毫伏为单位的平均zeta电位。
我们发现对照组的平均红细胞ZP为23.41毫伏（±1.87），而高血压患者的红细胞ZP为16.05（±1.72）毫伏，患有糖尿病的高血压患者的红细胞ZP更低，在6.96毫伏至22.76（+3.88）毫伏之间，同时伴有红细胞结构畸形和渗透脆性增加。
数据表明，与健康志愿者相比，红细胞结构存在形态学变化，渗透脆性增加，且ZP值显著降低，这可能是心血管疾病发展进程的主要原因。
