Barroso-Moguel R, Villeda-Hernández J, Méndez-Armenta M, Santamaría A, Galván-Arzate S
Laboratory of Cellular Neuromorphology, National Institute of Neurology and Neurosurgery, Mexico DF, Mexico.
Toxicol Lett. 1999 Oct 29;110(1-2):113-8. doi: 10.1016/s0378-4274(99)00148-4.
In this work, alveolar lesions induced after systemic administration of cocaine (30 mg/kg per day, i.p.) to rats were evaluated both by light microscope analysis for morphological assessment as well as by measurement of the alveolar area as a quantitative index of the alveolar damage. Rats were examined after different times of exposure: 7, 15, 30, 45, 60 and 75 days. The histopathological evaluation of cocaine-treated rats revealed a remarkable thickening in some interalveolar septa, with interstitial hemorrhages, progressive thrombosis and transformation of reticular and elastic fibers into diffuse fibrosis. A significant decrease of the alveolar area was also observed. These findings are indicative of severe changes in capillaries, alveoli and bronchiole after cocaine exposure, which in turn may progressively disrupt the general function of the lungs. Differential mechanisms of systemic toxicity after cocaine exposure are discussed.
在本研究中，通过光学显微镜分析进行形态学评估以及测量肺泡面积作为肺泡损伤的定量指标，对给大鼠腹腔注射可卡因（每天30毫克/千克）后诱导的肺泡病变进行了评估。在不同的暴露时间后对大鼠进行检查：7天、15天、30天、45天、60天和75天。对可卡因处理的大鼠进行的组织病理学评估显示，一些肺泡间隔明显增厚，伴有间质出血、进行性血栓形成以及网状和弹性纤维转化为弥漫性纤维化。还观察到肺泡面积显著减少。这些发现表明可卡因暴露后毛细血管、肺泡和细支气管发生了严重变化，进而可能逐渐破坏肺的整体功能。本文讨论了可卡因暴露后全身毒性的不同机制。
