Yildirim C, Kocoglu H, Goksu S, Cengiz B, Sari I, Bagci C
Department of Emergency Medicine, Gaziantep University Faculty of Medicine, Gaziantep, Turkey.
Inhal Toxicol. 2004 Dec 15;16(14):911-5. doi: 10.1080/08958370490520749.
In this study, we aimed to investigate the long-term histopathologic changes in the lungs of rats exposed to a high concentration of chlorine gas. Twenty-four Sprague-Dawley rats were divided into three groups: the control group (group I) (n = 8), early-examined group (group II) (n = 8), and late-examined group (group III) (n = 8). In group II the lungs of rats were taken out just after the exposure, whereas in group III the lungs were taken out 45 days after the exposure. Eosinophilic liquid accumulation in alveoli and bronchi, diffuse intraalveolar edema, vascular congestion, severe perivascular edema, and free bleeding in intraalveolar and interstitial area were observed in the lungs of rats in group II. Interstitial fibrosis and thickening of the alveolar septa were observed in group III. These findings suggest that the people using these cleaning agents are at risk of harming themselves, and the victims of chlorine gas injury should be reexamined at a later period since they may have pulmonary damage even after 45 days of exposure.
在本研究中，我们旨在调查暴露于高浓度氯气的大鼠肺部的长期组织病理学变化。将24只Sprague-Dawley大鼠分为三组：对照组（I组）（n = 8）、早期检查组（II组）（n = 8）和晚期检查组（III组）（n = 8）。II组大鼠在暴露后立即取出肺部，而III组大鼠在暴露后45天取出肺部。在II组大鼠的肺部观察到肺泡和支气管内嗜酸性液体积聚、弥漫性肺泡水肿、血管充血、严重的血管周围水肿以及肺泡内和间质区域的游离出血。在III组观察到间质纤维化和肺泡间隔增厚。这些发现表明，使用这些清洁剂的人有伤害自己的风险，氯气中毒受害者应在后期重新检查，因为即使在暴露45天后他们仍可能有肺部损伤。
