耻垢分枝杆菌中内源性内切-D-阿拉伯糖苷酶的存在及其寡聚阿拉伯糖苷产物的特性
The presence of an endogenous endo-D-arabinase in Mycobacterium smegmatis and characterization of its oligoarabinoside product.
作者信息
Xin Y, Huang Y, McNeil M R
机构信息
Department of Microbiology, Colorado State University, Fort Collins, CO 80523, USA.
出版信息
Biochim Biophys Acta. 1999 Dec 27;1473(2-3):267-71. doi: 10.1016/s0304-4165(99)00204-4.
Abstract
Endogenous mycobacterial endo-D-arabinase activity, which degrades cell wall polysaccharide arabinogalactan, was found in Mycobacterium smegmatis. The arabinan product contains 20-30 arabinosyl residues but no galactofuranosyl residues. Recognition of this endogenous activity results in the possibility of developing antituberculosis drugs that do not require bacterial growth for activity.
摘要
在耻垢分枝杆菌中发现了内源性分枝杆菌内切-D-阿拉伯糖苷酶活性，该酶可降解细胞壁多糖阿拉伯半乳聚糖。阿拉伯聚糖产物含有20-30个阿拉伯糖基残基，但不含呋喃半乳糖基残基。认识到这种内源性活性使得开发出无需细菌生长即可发挥活性的抗结核药物成为可能。
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