Hayashi T, Konishi S, Hasegawa I, Miyashita Y
Department of Physiology, The University of Tokyo School of Medicine, Tokyo, Japan.
Eur J Neurosci. 1999 Dec;11(12):4451-6. doi: 10.1046/j.1460-9568.1999.00892.x.
Functional magnetic resonance imaging (fMRI) in macaque monkeys is emerging as a potent candidate to bridge the gap between data from human fMRI studies and data from anatomy, electrophysiology and lesion studies in monkeys. The primary (SI) and secondary (SII) somatosensory cortices are the principal regions for somatosensory information processing and contain systematic representations of the body surface map (somatotopy). To examine the functional organization of the somatosensory cortices in anaesthetized macaque monkeys with fMRI, we asked whether focal and differential activation could be observed in SI and SII in response to tactile stimulation with two parameters: body sides (right and left) and body regions (hand and face). We found that changes in stimulus parameters elicited differential focal activation in both SI and SII in two ways. First, the hand and face stimulation activated SI and SII in the contralateral, but not in the ipsilateral, hemisphere. Second, the hand and face stimulation differentially activated two adjacent regions in both SI and SII. These fMRI results appear to correlate with previous mapping studies by other methods in the macaque somatosensory cortices. This study shows the feasibility of fMRI studies in mapping multiple sensory areas in monkeys by which we can distinguish between adjacent functionally distinct regions.
猕猴的功能磁共振成像（fMRI）正逐渐成为弥合人类fMRI研究数据与猕猴解剖学、电生理学和损伤研究数据之间差距的有力候选方法。初级体感皮层（SI）和次级体感皮层（SII）是体感信息处理的主要区域，包含体表图谱（躯体感觉定位）的系统表征。为了用fMRI研究麻醉猕猴体感皮层的功能组织，我们研究了在SI和SII中，是否能观察到对具有两个参数（身体侧别：右侧和左侧；身体部位：手部和面部）的触觉刺激产生的局灶性和差异性激活。我们发现，刺激参数的变化以两种方式在SI和SII中引发了差异性局灶性激活。首先，手部和面部刺激激活了对侧半球的SI和SII，但未激活同侧半球。其次，手部和面部刺激在SI和SII中差异性激活了两个相邻区域。这些fMRI结果似乎与之前在猕猴体感皮层中通过其他方法进行的图谱研究结果相关。这项研究表明了fMRI研究在绘制猕猴多个感觉区域图谱方面的可行性，通过该方法我们可以区分相邻的功能不同区域。
