Mazzotta G, Sarchielli P, Alberti A, Gallai V
Interuniversity Centre for the Study of Headache and Neurotransmitter Disorders, Perugia-Rome-Sassari-Bari-Naples, Italy.
Cephalalgia. 1999 Nov;19(9):802-9. doi: 10.1046/j.1468-2982.1999.1909802.x.
One-hundred-and-twenty-eight young headache outpatients underwent an electromyographical (EMG) ischemic test and determination of Mg++ levels in red and mononuclear blood cells. In migraine patients, with and without aura (MwA and MwoA), Mg++ concentration in the erythrocytes and in mononuclear cells was significantly reduced compared to tension-type headache (TTH) patients and healthy controls (p < 0.0001). The EMG ischemic test was positive in 71% of migraineurs, but only in 9.5% of TTH patients. Low intra-erythrocyte and mononuclear cell levels were evident in 84.3% and 81.2% of migraine patients, respectively; those whose ischemic tests were positive had intra-erythrocyte and mononuclear cell levels of Mg++ below the norm, respectively. However, reduced levels of Mg++ in erythrocytes were found in only two patients with TTH, and in mononuclear cells in one patient with TTH. These data provide further confirmation of the role of Mg++ in determining the status of neuromuscular hyperexcitability in about two-thirds of migraine patients, including childhood and adolescence. They also support the validity of carrying out EMG ischemic testing for distinguishing this condition, which can be corrected with adequate oral Mg++ supplementation and with a possible positive impact on headache.
128名年轻的头痛门诊患者接受了肌电图（EMG）缺血试验以及红细胞和单核细胞中镁离子（Mg++）水平的测定。在伴有或不伴有先兆的偏头痛患者（MwA和MwoA）中，与紧张型头痛（TTH）患者及健康对照相比，红细胞和单核细胞中的Mg++浓度显著降低（p < 0.0001）。EMG缺血试验在71%的偏头痛患者中呈阳性，但在TTH患者中仅为9.5%。在84.3%和81.2%的偏头痛患者中，分别明显存在红细胞内和单核细胞内Mg++水平低的情况；缺血试验呈阳性的患者红细胞内和单核细胞内的Mg++水平分别低于正常范围。然而，仅在两名TTH患者的红细胞中发现Mg++水平降低，在一名TTH患者的单核细胞中发现Mg++水平降低。这些数据进一步证实了Mg++在约三分之二的偏头痛患者（包括儿童和青少年）中决定神经肌肉兴奋性过高状态方面的作用。它们还支持进行EMG缺血试验以鉴别这种疾病的有效性，这种疾病可以通过适当口服补充Mg++得到纠正，并可能对头痛产生积极影响。
