The basic pathogenetic mechanisms of the development of the main forms of headache, namely the migraine (M) and the tension-type headache (TTH) are discussed. In migraine are examined alterations in three important links such as the states of brain, peripheral vessels, and trigeminal system both between the fits and during the attacks. Factors provoking the attacks were considered too. The modern scheme of TTH pathogenesis was described. Main unsolved problems of M and TTH pathogenesis and therapy are also presented.
