Kockx M, Leenen R, Seidell J, Princen H M, Kooistra T
Gaubius Laboratory TNO-PG, Leiden, The Netherlands.
Thromb Haemost. 1999 Nov;82(5):1490-6.
This study was aimed at evaluating the relationship between visceral fat accumulation and plasma plasminogen activator inhibitor-1 (PAI-1) levels in healthy, obese men and women undergoing weight loss therapy. The subjects, 25 men and 25 premenopausal women, aged between 26 and 49 years, with an initial body mass index between 28 and 38 kg/m2, received a controlled diet for 13 weeks providing a 4.2 MJ/day energy deficit. Magnetic resonance imaging was used to measure visceral and subcutaneous abdominal fat. Our results show that before weight loss visceral fat was significantly correlated with PAI-1 in men (r = 0.45; p<0.05), but not in women (r = -0.15; ns). The association between visceral fat and PAI-1 in men remained significant after adjustment for age and total fat mass, and multiple linear regression analysis showed a significant independent contribution of visceral fat to plasma PAI-1 levels. Both visceral fat areas and PAI-1 levels decreased significantly with weight loss in both men and women. Changes in visceral fat area were related to changes in PAI-1 in women (r = -0.43; p = 0.05) but not in men (r = -0.01; ns); however, this association in women disappeared after adjustment for total fat mass. We conclude that there is a relationship between visceral fat and PAI-1 in obese men but not in obese women, and that PAI-1 levels decrease substantially (52%) by weight loss, but this change is not related to changes in visceral fat mass per se.
本研究旨在评估接受减肥治疗的健康肥胖男性和女性内脏脂肪堆积与血浆纤溶酶原激活物抑制剂 -1（PAI -1）水平之间的关系。研究对象为25名男性和25名绝经前女性，年龄在26至49岁之间，初始体重指数在28至38 kg/m²之间，接受了为期13周的控制饮食，每日能量摄入减少4.2兆焦耳。采用磁共振成像测量腹部内脏脂肪和皮下脂肪。我们的研究结果表明，在减肥前，男性内脏脂肪与PAI -1显著相关（r = 0.45；p<0.05），而女性则不然（r = -0.15；无统计学意义）。在对年龄和总脂肪量进行校正后，男性内脏脂肪与PAI -1之间的关联仍然显著，多元线性回归分析显示内脏脂肪对血浆PAI -1水平有显著的独立贡献。男性和女性的内脏脂肪面积和PAI -1水平均随着体重减轻而显著下降。女性内脏脂肪面积的变化与PAI -1的变化相关（r = -0.43；p = 0.05），而男性则不然（r = -0.01；无统计学意义）；然而，在对总脂肪量进行校正后，女性的这种关联消失了。我们得出结论，肥胖男性内脏脂肪与PAI -1之间存在关系，而肥胖女性则不然，且减肥可使PAI -1水平大幅下降（52%），但这种变化与内脏脂肪量本身的变化无关。
