Ross Robert, Janssen Ian, Dawson Jody, Kungl Ann-Marie, Kuk Jennifer L, Wong Suzy L, Nguyen-Duy Thanh-Binh, Lee SoJung, Kilpatrick Katherine, Hudson Robert
School of Physical and Health Education, Department of Medicine, Division of Endocrinology and Metabolism, Queen's University, Kingston, Ontario, Canada.
Obes Res. 2004 May;12(5):789-98. doi: 10.1038/oby.2004.95.
To determine the effects of equivalent diet- or exercise-induced weight loss and exercise without weight loss on subcutaneous fat, visceral fat, and insulin sensitivity in obese women.
Fifty-four premenopausal women with abdominal obesity [waist circumference 110.1 +/- 5.8 cm (mean +/- SD)] (BMI 31.3 +/- 2.0 kg/m2) were randomly assigned to one of four groups: diet weight loss (n = 15), exercise weight loss (n = 17), exercise without weight loss (n = 12), and a weight-stable control group (n = 10). All groups underwent a 14-week intervention.
Body weight decreased by approximately 6.5% within both weight loss groups and was unchanged in the exercise without weight loss and control groups. In comparison with controls, cardiorespiratory fitness improved within the exercise groups only (p < 0.01). Reduction in total, abdominal, and abdominal subcutaneous fat within the exercise weight loss group was greater (p < 0.001) than within all other groups. The reduction in total and abdominal fat within the diet weight loss and exercise without weight loss groups was greater than within controls (p < 0.001) but not different from each other (p > 0.05). Visceral fat decreased within all treatment groups (p < 0.008), and these changes were not different from each other. In comparison with the control group, insulin sensitivity improved within the exercise weight loss group alone (p < 0.001).
Daily exercise without caloric restriction was associated with substantial reductions in total fat, abdominal fat, visceral fat, and insulin resistance in women. Exercise without weight loss was also associated with a substantial reduction in total and abdominal obesity.
确定等量饮食或运动诱导的体重减轻以及无体重减轻的运动对肥胖女性皮下脂肪、内脏脂肪和胰岛素敏感性的影响。
54名绝经前腹部肥胖的女性腰围110.1±5.8厘米（均值±标准差）被随机分为四组之一：饮食减重组（n = 15）、运动减重组（n = 17）、无体重减轻的运动组（n = 12）和体重稳定的对照组（n = 10）。所有组均接受为期14周的干预。
两个减重组的体重均下降了约6.5%，无体重减轻的运动组和对照组体重未变。与对照组相比，仅运动组的心肺适能有所改善（p<0.01）。运动减重组的总脂肪、腹部脂肪和腹部皮下脂肪减少量比所有其他组更大（p<0.001）。饮食减重组和无体重减轻的运动组的总脂肪和腹部脂肪减少量大于对照组（p<0.001），但两组之间无差异（p>0.05）。所有治疗组的内脏脂肪均减少（p<0.008），且这些变化相互之间无差异。与对照组相比，仅运动减重组的胰岛素敏感性有所改善（p<0.001）。
不限制热量摄入的日常运动与女性总脂肪、腹部脂肪、内脏脂肪和胰岛素抵抗的大幅降低有关。无体重减轻的运动也与总肥胖和腹部肥胖的大幅降低有关。
