Sturzenegger M
Neurologische Universitätsklinik, Inselspital, Bern.
Ther Umsch. 1999 Nov;56(11):675-9. doi: 10.1024/0040-5930.56.11.675.
The interest in prion diseases, particularly the Creutzfeldt-Jakob type (CJD), rose dramatically in the last years for two reasons. 1) The general public wants to know whether eating beef may cause CJD. Discovering the new variant Creutzfeldt-Jakob disease (nvCJD) and experimental evidence that nvCJD and bovine spongiforme encephalopathy (BSE) are caused by the same prion strain make this idea probable. 2) Infectiologists and Neuroscientists recognise a model disease for a new infectious principle in that the same disease may occur as being inherited as well as transmitted. Additionally, it might allow new insights into the possible aetiologies of neurodegenerative disease.
在过去几年中，人们对朊病毒疾病，尤其是克雅氏病（CJD）的兴趣急剧上升，原因有两个。1）公众想知道食用牛肉是否会导致克雅氏病。新型变异型克雅氏病（nvCJD）的发现以及nvCJD与牛海绵状脑病（BSE）由同一朊病毒株引起的实验证据，使得这种想法具有了可能性。2）传染病学家和神经科学家将其视为一种新的感染原理的典型疾病，因为同一种疾病既可能遗传，也可能传播。此外，它可能会为神经退行性疾病的可能病因带来新的见解。
