Yamaguchi K, Nagasawa S, Kawabata S, Kawanishi M, Tada Y, Ohta T
Department of Neurosurgery, Osaka Medical College, Takatsuki, Japan.
Neurol Res. 1999 Dec;21(8):733-6. doi: 10.1080/01616412.1999.11741006.
Hemodynamics of paraclinoid aneurysms were investigated focusing on the effects of their locations and shape of the carotid siphon. A transparent silicon model of the carotid siphon was constructed and a model aneurysm was attached to the outside of the curvature at three different sites. Glycerol solution was perfused into the model, and the half-life of the dye injected into the aneurysm was calculated as an index of the stagnant flow. Values of half-life changed significantly depending on the aneurysmal location and the siphon angle. When the siphon angle was 0 degree where C2 and C4 segments were parallel to each other, the half-life value was the lowest in the C2-C3 junction aneurysm, highest in the C3 segment aneurysm and intermediate in the C2 segment aneurysm. While the C2-C3 junction aneurysm maintained low values regardless of the angle, the C3 segment aneurysm values decreased and C2 segment aneurysm values increased with increases in the angle. These changes of half-life occur because the point at which the faster moving fluid component strikes the curved wall changes according to the siphon angle. These results are considered useful to determine the surgical indications, treatment modalities and post-surgical management of the aneurysms.
以海绵窦段动脉瘤的位置及颈动脉虹吸部形态的影响为重点，对其血流动力学进行了研究。构建了颈动脉虹吸部的透明硅模型，并在三个不同部位将模型动脉瘤附着于弯曲部外侧。将甘油溶液灌注到模型中，并计算注入动脉瘤的染料的半衰期，作为血流停滞的指标。半衰期值因动脉瘤位置和虹吸角度的不同而有显著变化。当虹吸角度为0度（即C2段和C4段相互平行）时，C2-C3交界处动脉瘤的半衰期值最低，C3段动脉瘤的半衰期值最高，C2段动脉瘤的半衰期值居中。虽然无论角度如何，C2-C3交界处动脉瘤的半衰期值都保持较低水平，但随着角度增加，C3段动脉瘤的半衰期值降低，C2段动脉瘤的半衰期值升高。半衰期的这些变化是因为快速流动的流体成分撞击弯曲壁的点会根据虹吸角度而改变。这些结果被认为有助于确定动脉瘤的手术指征、治疗方式及术后管理。
