Aréchiga-Urtuzuástegui H
Instituto Nacional de Neurología y Neurocirugía, México, D.F.
Gac Med Mex. 1999 Sep-Oct;135(5):489-99.
Over the last decade, a considerable wealth of information has expanded and strengthened our knowledge of the relations between the nervous, endocrine, and immune systems. The following areas of progress may be underlined 1) the cells of the three systems appear to secrete similar substances and are sensitive to them, thus suppressing traditional differences between neurotransmitters, hormones and immune mediators; 2) new knowledge is available on hormone actions on the immune system, and direct and mutual influences between the nervous and the immune system have been documented; 3) brain areas selectively involved in immune regulation have been identified; 4) various brain functions are now known to be influenced by immune mediators; 5) neurological and psychiatric components have been described in autoimmune diseases. An immune etiology has been unraveled in a wide range of neural disorders. A neuroimmunological component has been documented in a growing number of diseases. Altogether, a new chapter is emerging in our understanding of homeostatic functions and their medical implications.
在过去十年中，大量丰富的信息扩展并强化了我们对神经、内分泌和免疫系统之间关系的认识。以下几个取得进展的领域值得强调：1）这三个系统的细胞似乎分泌相似的物质并对其敏感，从而模糊了神经递质、激素和免疫介质之间的传统差异；2）关于激素对免疫系统作用的新知识不断涌现，并且神经和免疫系统之间的直接及相互影响已有文献记载；3）已确定了选择性参与免疫调节的脑区；4）现在已知各种脑功能会受到免疫介质的影响；5）自身免疫性疾病中的神经和精神成分已被描述。多种神经疾病的免疫病因已被揭示。越来越多的疾病中记录到了神经免疫学成分。总之，我们对稳态功能及其医学意义的理解正在开启新的篇章。
