Akmaev I G
Institute of Experimental Endocrinology, Russian Endocrinology Research Centre, Moscow.
Usp Fiziol Nauk. 1996 Jan-Mar;27(1):3-20.
Three regulating systems, nervous, endocrine and immune, are involved in maintenance of homeostasis. They are regarded as interacting, with interaction between nervous and endocrine systems being well defined and giving rise to development of independent realm of knowledge--the neuroendocrinology. As concerns interaction between the neuroendocrine and immune systems it seems to be exciting and intensely developing trend of up-to-date investigation. A great deal of evidence is adduced bringing new sight into the mechanisms of bidirectional exchange of signals among the nervous, endocrine and immune systems. This paper provides analytical consideration of the vast information, that allowed the development of the new integrative area of biology--the neuro-immuno-endocrinology, with special reference being paid to some general regularities underlying integration of each regulatory constituents into the single operating system. Attention is also paid to up-date information concerning mechanisms of neurotransmition and immune response in terms of the problem under consideration.
神经、内分泌和免疫这三个调节系统参与体内稳态的维持。它们被视为相互作用的，神经和内分泌系统之间的相互作用已得到充分阐明，并催生了一个独立的知识领域——神经内分泌学的发展。至于神经内分泌系统和免疫系统之间的相互作用，这似乎是当代研究中一个令人兴奋且发展迅速的趋势。大量证据被提出，为神经、内分泌和免疫系统之间双向信号交换的机制带来了新的认识。本文对大量信息进行了分析思考，这些信息促成了生物学新的综合领域——神经免疫内分泌学的发展，特别提及了将每个调节成分整合到单一操作系统中的一些一般规律。同时也关注了与所讨论问题相关的神经传递和免疫反应机制的最新信息。
