Mirand E A, Gordon A D, Murphy G P
J Med. 1975;6(3-4):261-70.
Erythropoietic activity produced by exogenous erythropoietin (Ep) is markedly reduced in Swiss mice rendered uremic by bilateral nephrectomy or bilateral ureteral ligation. Exogenous Ep causes a greater increase in erythropoiesis in germfree Swiss mice as compared with non-germfree mice, but the germfree mice show a more drastic reduction of erythropoiesis in uremia. Heme production in blood, spleen, and femoral marrow retains its typical pattern in uremia; there is no shift of erythropoiesis among the three sites. Production of endogenous Ep in uremic mice is less by a factor of 2-3 than that in intact mice whereas the reduction is by a factor of almost 100 in anephric mice. The data suggest that the anemia associated with uremia is the result of two phenomena: (1) a decreased production of Ep and (2) a diminished erythropoietic response to Ep.
通过双侧肾切除或双侧输尿管结扎使瑞士小鼠产生尿毒症后，外源性促红细胞生成素（Ep）所产生的促红细胞生成活性显著降低。与无菌小鼠相比，外源性Ep在无菌瑞士小鼠中引起的红细胞生成增加幅度更大，但无菌小鼠在尿毒症时红细胞生成的减少更为明显。血液、脾脏和股骨骨髓中的血红素生成在尿毒症时保持其典型模式；三个部位之间的红细胞生成没有转移。尿毒症小鼠内源性Ep的产生比完整小鼠少2 - 3倍，而无肾小鼠的减少几乎达100倍。数据表明，与尿毒症相关的贫血是两种现象的结果：（1）Ep产生减少；（2）对Ep的促红细胞生成反应减弱。
