酒精中毒、单胺氧化酶活性和P300波幅与12号染色体q24区域标记物之间可能存在的联系。

Possible linkage of alcoholism, monoamine oxidase activity and P300 amplitude to markers on chromosome 12q24.

作者信息

Juo S H, Pugh E W, Baffoe-Bonnie A, Kingman A, Sorant A J, Klein A P, O'Neill J, Mathias R A, Wilson A F, Bailey-Wilson J E

机构信息

National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.

出版信息

Genet Epidemiol. 1999;17 Suppl 1:S193-8. doi: 10.1002/gepi.1370170733.

DOI:10.1002/gepi.1370170733

PMID:10597435

Abstract

Multipoint linkage analysis was used to screen for evidence of linkage between alcoholism and five alcoholism-related quantitative traits. The results suggest that a susceptibility locus that influences monoamine oxidase activity and P300 amplitude at the Pz lead, and increases the risk of alcohol dependence may be linked to markers in the 12q24 region. Furthermore, the susceptibility for alcoholism may be associated with allele 3 (allele size 144) of D12S392.

摘要

采用多点连锁分析来筛查酗酒与五个酗酒相关数量性状之间的连锁证据。结果表明，一个影响单胺氧化酶活性和Pz导联P300波幅并增加酒精依赖风险的易感基因座可能与12q24区域的标记物连锁。此外，酗酒易感性可能与D12S392的等位基因3（等位基因大小144）相关。