多变量定性和定量性状的联合多点连锁分析。II. 酗酒与事件相关电位。
Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. II. Alcoholism and event-related potentials.
作者信息
Williams J T, Begleiter H, Porjesz B, Edenberg H J, Foroud T, Reich T, Goate A, Van Eerdewegh P, Almasy L, Blangero J
机构信息
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USA.
出版信息
Am J Hum Genet. 1999 Oct;65(4):1148-60. doi: 10.1086/302571.
Abstract
The availability of robust quantitative biological markers that are correlated with qualitative psychiatric phenotypes can potentially improve the power of linkage methods to detect quantitative-trait loci influencing psychiatric disorders. We apply a variance-component method for joint multipoint linkage analysis of multivariate discrete and continuous traits to the extended pedigree data from the Collaborative Study on the Genetics of Alcoholism, in a bivariate analysis of qualitative alcoholism phenotypes and quantitative event-related potentials. Joint consideration of the DSM-IV diagnosis of alcoholism and the amplitude of the P300 component of the Cz event-related potential significantly increases the evidence for linkage of these traits to a chromosome 4 region near the class I alcohol dehydrogenase locus ADH3. A likelihood-ratio test for complete pleiotropy is significant, suggesting that the same quantitative-trait locus influences both risk of alcoholism and the amplitude of the P300 component.
摘要
与定性精神疾病表型相关的可靠定量生物学标志物的可用性，有可能提高连锁分析方法检测影响精神疾病的数量性状位点的能力。我们将一种用于多变量离散和连续性状联合多点连锁分析的方差成分法应用于来自酒精中毒遗传学合作研究的扩展家系数据，对定性酒精中毒表型和定量事件相关电位进行双变量分析。联合考虑DSM-IV酒精中毒诊断和Cz事件相关电位P300成分的幅度，显著增加了这些性状与位于I类酒精脱氢酶基因座ADH3附近的4号染色体区域连锁的证据。完全多效性的似然比检验具有显著性，表明相同的数量性状位点影响酒精中毒风险和P300成分的幅度。
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